Investigation into the erosion mechanism of salicylate-based poly(anhydride-esters)
Investigation into the erosion mechanism of salicylate-based poly(anhydride-esters)
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DOI：
10.1002/jbm.a.30356
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发表时间：
2006-03-01
影响因子：
4.9
通讯作者：
Uhrich, K
中科院分区：
文献类型：
--
作者：
Whitaker-Brothers, K;Uhrich, K
基于水杨酸的聚酸酐酯，统称为聚阿司匹林（TM），水解降解为水杨酸，一种非甾体类抗炎药（NSAID）。本文研究的聚酸酐酯的变化是由己二酸、亚酰基酸或癸二酸连接的。阐明其侵蚀机理。聚合物、吸水率、质量损失、接触角和器件厚度的变化作为体外降解时间的函数进行监测。这里检查的聚合物似乎主要经历了表面侵蚀。己二酸均聚物吸收了最多的水，因此比其他形式的聚酸酐酯膨胀得更大。此外，己二酸均聚物腐蚀最快。增加连接段的长度降低了水解的驱动力，延长了聚合物样品的使用寿命。(C) 2005 Wiley期刊有限公司
Salicylate-based poly(anhydride-esters), collectively referred to as PolyAspirin(TM), hydrolytically degrade into salicylic acid, a nonsteioidal anti-inflammatory drug (NSAID). The variations of the poly(anhydride-ester) investigated in this article are linked by adipic acid, suberic acid, or sebacic acid. To elucidate the erosion mechanism of these. polymers, water uptake, mass loss, contact angle, and changes in device thickness were monitored as a function of in vitro degradation time. The polymers examined here appeared to primarily undergo surface erosion. The adipate homopolymer absorbed the most water and therefore swelled more than the other versions of the poly(anhydride-ester). Additionally, the adipate homopolymer eroded most quickly. Increasing the length of the linker moiety decreased the driving force for hydrolysis, which prolonged the lifetime of the polymer sample. (C) 2005 Wiley Periodicals, Inc.