Dynamic Kinetic Resolution of Azlactones Catalyzed by Chiral Bronsted Acids
Dynamic Kinetic Resolution of Azlactones Catalyzed by Chiral Bronsted Acids
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DOI：
10.1021/ol102736t
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发表时间：
2011-02-04
期刊：
影响因子：
5.2
通讯作者：
Birman, Vladimir B.
中科院分区：
文献类型：
--
作者：
Lu, Guojian;Birman, Vladimir B.
手性布朗斯台德酸首次被证明可以催化吖内酯的动态动力学拆分。 3,3'-双-(9-蒽基)-BINOL 磷酸 3c 在 4-芳基取代底物的情况下特别有效，产生 85-92% ee。
Chiral Bronsted acids have been shown for the first time to catalyze the dynamic kinetic resolution of azlactones. 3,3'-Bis-(9-anthryl)-BINOL phosphoric acid 3c is particularly effective in the case of 4-aryl-substituted substrates, producing 85-92% ee's.