NATURAL HUMAN ANTIBODIES TO GRAM-NEGATIVE BACTERIA - IMMUNOGLOBULINS G A AND M
NATURAL HUMAN ANTIBODIES TO GRAM-NEGATIVE BACTERIA - IMMUNOGLOBULINS G A AND M
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DOI：
10.1126/science.152.3726.1257
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发表时间：
1966-01-01
期刊：
影响因子：
56.9
通讯作者：
NORINS, LC
中科院分区：
文献类型：
--
作者：
COHEN, IR;NORINS, LC
通过免疫荧光技术，在成人血清中检测到大量的免疫球蛋白G和M，以及少量与淋病奈瑟菌和大肠杆菌反应的天然抗体。脐带血清中也含有大量的免疫球蛋白-G抗体，但很少或没有M或A。这些发现挑战了与革兰氏阴性菌反应的天然抗体主要是免疫球蛋白-M类的概念。
Significant amounts of immunoglobulins G and M, and a small amount of natural antibodies reactive with Neisseria gonorrhoeae and Escherichia coli, have been detected in human adult serums by immunofluorescent techniques. Umbilical cord serums also contained substantial immuno-globulin-G antibody but little or no M or A. These findings challenge the concept that natural antibodies reactive with Gram-negative bacteria are primarily of the immunoglobulin-M class.