Pathophysiology of Aortic Aneurysms: Insights from Animal Studies.
Pathophysiology of Aortic Aneurysms: Insights from Animal Studies.
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DOI：
10.26502/fccm.92920146
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发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Liu B
中科院分区：
文献类型：
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作者：
Khoury MK;Stranz AR;Liu B
主动脉瘤的定义是主动脉扩张超过50%。目前，主动脉瘤的唯一有效治疗方法是手术修复，仅推荐给符合标准的患者。没有可用的药物治疗来减缓动脉瘤生长，从而防止致命的破裂。许多小鼠模型的开发允许深入研究动脉瘤病理生理学的各种细胞和细胞外成分。关键治疗靶点的确定导致了几项临床试验，评估治疗动脉瘤进展的候选药物。在这篇综述中，我们重点提供了最近的更新，在小鼠模型的主动脉瘤的发展。此外，我们还讨论了主动脉沿着与相邻主动脉结构的各种细胞和细胞外成分的最新研究，这些成分有助于动脉瘤的发展和进展。
Aortic aneurysms are defined as dilations of the aorta greater than 50 percent. Currently, the only effective treatment for aortic aneurysms is surgical repair, which is recommended only to those that meet criteria. There is no available pharmaceutical therapy to slow aneurysm growth and thus prevent lethal rupture. The development of a number of murine models has allowed in depth studies of various cellular and extracellular components of aneurysm pathophysiology. The identification of key therapeutic targets has resulted in several clinical trials evaluating pharmaceutical candidates to treat aneurysm progression. In this review, we focus on providing recent updates on developments in murine models of aortic aneurysm. In addition, we discuss recent studies of the various cellular and extracellular components of the aorta along with the abutting aortic structures that contribute to aneurysm development and progression.