Modified Look-Locker T1 evaluation using Bloch simulations: Human and phantom validation
Modified Look-Locker T1 evaluation using Bloch simulations: Human and phantom validation
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DOI：
10.1002/mrm.24251
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发表时间：
2013-02-01
影响因子：
3.3
通讯作者：
Bluemke, David A.
中科院分区：
文献类型：
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作者：
Gai, Neville D.;Stehning, Christian;Bluemke, David A.
改良的 Look-Locker 成像经常用于心肌的 T1 映射。然而，各种 MRI 参数（例如编码方案、翻转角度的修改、心率、T2 和反转时间）对 T1 测量精度的具体影响尚未通过 Bloch 模拟进行研究。在这项工作中，改进的 Look-Locker 成像通过布洛赫方程的数值解来表征。可能影响 T1 准确性的 MRI 序列参数在模拟中被系统地改变。为了验证，使用不同的 T2 和 T1 时间构建模型，并与 Bloch 方程模拟进行比较。还使用各种脉冲序列参数对人类志愿者进行了评估，以评估数值模拟的有效性。模拟 T1 时间与模型和志愿者中测量的 T1 时间非常一致。降低 T2 时间（即
Modified Look-Locker imaging is frequently used for T1 mapping of the myocardium. However, the specific effect of various MRI parameters (e.g., encoding scheme, modifications of flip angle, heart rate, T2, and inversion times) on the accuracy of T1 measurement has not been studied through Bloch simulations. In this work, modified Look-Locker imaging was characterized through a numerical solution for Bloch equations. MRI sequence parameters that may affect T1 accuracy were systematically varied in the simulation. For validation, phantoms were constructed with various T2 and T1 times and compared with Bloch equation simulations. Human volunteers were also evaluated with various pulse sequences parameters to assess the validity of the numerical simulations. There was close agreement between simulated T1 times and T1 times measured in phantoms and volunteers. Lower T2 times (i.e.,