Phylogeny-directed search for murine leukemia virus-like retroviruses in vertebrate genomes and in patients suffering from myalgic encephalomyelitis/chronic fatigue syndrome and prostate cancer.
Phylogeny-directed search for murine leukemia virus-like retroviruses in vertebrate genomes and in patients suffering from myalgic encephalomyelitis/chronic fatigue syndrome and prostate cancer.
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DOI：
10.1155/2011/341294
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发表时间：
2011
影响因子：
2.2
通讯作者：
Sperber G
中科院分区：
文献类型：
--
作者：
Blomberg J;Sheikholvaezin A;Elfaitouri A;Blomberg F;Sjösten A;Mattson Ulfstedt J;Pipkorn R;Källander C;Ohrmalm C;Sperber G
大多数脊椎动物基因组中都有类似γ -逆转录病毒的序列。鼠白血病病毒（MLV）样逆转录病毒（mllv）是一个亚群，可能具有致病性并跨物种传播。从患有前列腺癌（PC）和肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的患者中报告的与mllv(异嗜性小鼠逆转录病毒相关病毒（XMRV）和人类小鼠逆转录病毒样逆转录病毒（hmrv）高度相似的逆转录病毒提高了人类也被感染的可能性。结构完整，具有潜在传染性的mllv存在于一些哺乳动物，特别是小鼠的基因组中。小鼠mllv包含三大类。一种是MERV G3，包含mlv和XMRV/HMRV。它在小鼠DNA中的存在，以及生物制品中丰富的异向性mlv，是假阳性的来源。理论上，XMRV/HMRV可能是几种MLLV跨物种感染之一。MLLV的病理生物学和多样性表明了研究人类XMRV/HMRV的最佳策略，并引起了伦理问题。XMRV/HMRV可能导致难以察觉的“隐形”感染，或者XMRV/HMRV从未感染到人类，这些都必须考虑。
Gammaretrovirus-like sequences occur in most vertebrate genomes. Murine Leukemia Virus (MLV) like retroviruses (MLLVs) are a subset, which may be pathogenic and spread cross-species. Retroviruses highly similar to MLLVs (xenotropic murine retrovirus related virus (XMRV) and Human Mouse retrovirus-like RetroViruses (HMRVs)) reported from patients suffering from prostate cancer (PC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) raise the possibility that also humans have been infected. Structurally intact, potentially infectious MLLVs occur in the genomes of some mammals, especially mouse. Mouse MLLVs contain three major groups. One, MERV G3, contained MLVs and XMRV/HMRV. Its presence in mouse DNA, and the abundance of xenotropic MLVs in biologicals, is a source of false positivity. Theoretically, XMRV/HMRV could be one of several MLLV transspecies infections. MLLV pathobiology and diversity indicate optimal strategies for investigating XMRV/HMRV in humans and raise ethical concerns. The alternatives that XMRV/HMRV may give a hard-to-detect “stealth” infection, or that XMRV/HMRV never reached humans, have to be considered.