New synthesis of vaulted biaryl ligands via the Snieckus phenol synthesis.
New synthesis of vaulted biaryl ligands via the Snieckus phenol synthesis.
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通过 Snieckus 苯酚合成新合成拱形联芳基配体。
DOI：
10.1021/ol047852e
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发表时间：
2005
期刊：
影响因子：
5.2
通讯作者：
Wulff,WilliamD
中科院分区：
文献类型：
--
作者：
Yu,Su;Rabalakos,Constantinos;Mitchell,WilliamD;Wulff,WilliamD
为了开发避免使用铬卡宾配合物的 VAPOL 配体的合成方法，研究了一种涉及通过 Snieckus 方法环化萘甲酰胺的路线。后者的衍生物可以通过两步序列转化为 2-苯基-4-菲酚，总产率为 60−72%。该方法在 VAPOL 衍生物合成中的实用性在 (S)-7,7'-二甲基-VAPOL 的合成中得到了证明。
In an effort to develop a synthesis of the VAPOL ligand that avoids the use of a chromium carbene complex, a route was examined that involved the annulation of a naphthalene carboxamide via the method of Snieckus. The latter derivatives could be converted in a two-step sequence to 2-phenyl-4-phenanthrols in 60−72% overall yields. The utility of this method for the synthesis of VAPOL derivatives is demonstrated in the synthesis of (S)-7,7‘-dimethyl-VAPOL.