ACTIVATION OF V-NU GENE REARRANGEMENT IN PRE-B-CELLS FOLLOWS THE EXPRESSION OF MEMBRANE-BOUND IMMUNOGLOBULIN HEAVY-CHAINS
ACTIVATION OF V-NU GENE REARRANGEMENT IN PRE-B-CELLS FOLLOWS THE EXPRESSION OF MEMBRANE-BOUND IMMUNOGLOBULIN HEAVY-CHAINS
复制标题
DOI：
10.1002/j.1460-2075.1987.tb02649.x
复制
发表时间：
1987-11-01
期刊：
影响因子：
11.4
通讯作者：
ALT, FW
中科院分区：
文献类型：
--
作者：
RETH, M;PETRAC, E;ALT, FW
B 细胞发育过程中 V.kappa。基因重排似乎仅发生在μ阳性前B细胞中。研究.mu的作用。 Ig.kappa 激活链。基因座，我们引入了携带不同形式的.mu的表达载体。基因进入无效的前B细胞。 Ig.kappa 的激活。基因座遵循.mu的膜形式(.mu.m)的表达。链。分泌形式(.mu.s)的表达不会导致Ig.kappa的激活。轨迹。我们进一步证明.mu 的两种形式。链在前 B 细胞中的细胞内运输方面有所不同。
During B cell development V.kappa. gene rearrangement seeems to occur only in .mu.-positive pre-B cells. To study the role of the .mu. chain in the activation of the Ig.kappa. locus, we introduced expression vectors carrying different forms of the .mu. gene into null pre-B cells. The activation of the Ig.kappa. locus followed the expression of the membrane form (.mu.m) of the .mu. chain. The expression of the secreted form (.mu.s) did not result in the activation of the Ig.kappa. locus. We further show that both forms of the .mu. chain differ in their intracellular transport in pre-B cells.