Osteopenia in the maxillofacial area: a study in sheep
Osteopenia in the maxillofacial area: a study in sheep
复制标题
颌面部骨质减少：绵羊研究
作者：
E. Veigel;R. Moore;M. Zarrinkalam;D. Schulze;S. Sauerbier;R. Schmelzeisen;P. Voss
骨质疏松症是世界范围内的一个主要公共卫生问题。其在创伤学和颌面种植学领域的意义有待探讨。采用大型动物模型评估腰椎和下颌骨的骨质流失。骨质疏松症是一种以骨量低和骨组织微结构退化为特征的常见病。骨质疏松相关骨折是一个主要的公共卫生负担。颌骨面骨质疏松症的存在及其相关性仍然存在争议。由于难以找到大型同质研究组，对人类的研究受到限制，并且出于伦理考虑，许多动物模型已用于骨质疏松症研究。本研究的目的是评估广泛性骨质减少的羊模型在颌面区域的变化。方法采用切除卵巢、肌肉注射糖皮质激素和低钙饮食诱导10只美利奴羊骨质流失。5只未经治疗的动物作为对照。在基线和1、3、6、9和12个月后，采用双能x线骨密度仪评估腰椎骨密度。腰椎和下颌骨活检并进行显微计算机断层扫描分析。结果干预组患者骨密度逐渐下降，6个月后降至最低（p < 0.001）。诱导组腰椎骨小梁骨体积(BV)/组织体积（TV）显著降低（p < 0.05）。两组下颌骨BV/TV变化均有统计学意义（p < 0.05）。下颌骨的其他参数也存在区域差异。干预组皮质宽度明显减小（p < 0.001）。结论诱导引起的绵羊微结构变化似乎具有普遍性。该羊模型符合颌面部进一步研究的标准。
SummaryOsteoporosis is a major public health problem worldwide. Its significance in the fields of traumatology and implantology of the maxillofacial area requires investigation. A large animal model was used to assess bone loss in the lumbar spine and mandible.IntroductionOsteoporosis is a prevalent disease characterized by low bone mass and microarchitectural deterioration of bone tissue. Osteoporosis-related fractures represent a major public health burden. The presence and relevance of osteoporosis in the maxillofacial area remain controversial. Research in humans is limited by difficulties in finding large homogenous study groups and, due to ethical considerations, numerous animal models have been used in osteoporosis research. The aim of this study was to assess a sheep model of generalized osteopenia for changes in the maxillofacial area.MethodsBone loss was induced in ten Merino sheep by ovariectomy, intramuscular administration of glucocorticoids, and a calcium-reduced diet. Five untreated animals served as controls. Bone mineral density (BMD) was assessed by dual-energy X-ray absorptiometry at the lumbar spine at baseline and after 1, 3, 6, 9, and 12 months. Lumbar and mandibular bone biopsies were obtained and analyzed with microcomputed tomography.ResultsLumbar BMD decreased progressively in the intervention group and was most significantly low after 6 months (p < 0.001). Lumbar trabecular bone showed a significant decrease in bone volume (BV)/tissue volume (TV; p < 0.05) in the inducted group. Significant changes were found in both analyzed mandibular regions for BV/TV (p < 0.05). Regional variations were found for other parameters in the mandible. The cortical width was substantially reduced in the intervention group (p < 0.001).ConclusionsMicrostructural changes occurring in sheep as a result of induction seem to have a generalized nature. This sheep model meets the criteria for further investigation in the maxillofacial area.
切除卵巢的绵羊作为人类骨质流失的模型。
DOI：
10.1016/j.jcpa.2003.12.007
发表时间：
2004
期刊：
Journal of comparative pathology.
影响因子：
--
作者：
Newton,BI;Cooper,RC;Gilbert,JA;Johnson,RB;Zardiackas,LD
通讯作者：
Zardiackas,LD