Atopy and depression:: results from the Northern Finland 1966 Birth Cohort Study
Atopy and depression:: results from the Northern Finland 1966 Birth Cohort Study
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DOI：
10.1038/sj.mp.4001274
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发表时间：
2003-01-01
影响因子：
11
通讯作者：
Räsänen, P
中科院分区：
文献类型：
--
作者：
Timonen, M;Jokelainen, J;Räsänen, P
几项研究表明，ige介导的特应性过敏与抑郁症之间存在关联。本研究扩展了我们对这种关联的假定性别差异的理解，并为我们之前的发现提供了进一步的流行病学证据，即特应性与抑郁症之间的关联可能仅针对女性。为了清楚地确定特应性疾病和抑郁症的存在，我们使用了比以前更有效的工具，并访问了一个数据库（芬兰北部1966年出生队列），其中对个体进行了前瞻性随访，直到31岁。通过皮肤点刺试验验证的过敏症状信息，包括5518个人的数据，用于确定变态反应的存在。在霍普金斯症状检查表-25和自我报告的医生诊断抑郁症的帮助下，对抑郁症进行了评估。在对父亲的社会阶层、母亲的胎次和居住地进行调整后，逻辑回归分析显示，患抑郁症的风险与抑郁症严重程度的增加平行增加，与非特应性受试者相比，特应性女性患抑郁症的风险增加了3.0至4.7倍，具有统计学意义。在特应性男性中，特应性与抑郁症之间的关联仅在抑郁症得分最高时具有统计学意义，优势比为6.3倍。结果表明，患有特应性疾病的女性可能在成年早期就有更高的患抑郁症的风险。在男性中，只有在最严重的抑郁症表现中，这两种疾病之间的联系才很明显。可能的背景理论，即遗传异常在5 -羟色胺代谢，hpa轴功能障碍和组胺理论进行了讨论。
Several studies have suggested an association between IgE-mediated atopic allergies and depression. The present study extends our understanding about putative gender differences of this association and provides further epidemiological evidence for our previous finding that the association between atopy and depression may be characteristic for females only. In order to clearly determine the presence of atopic disorders and depression, we used more valid tools than had been employed earlier and we had access to a database (the Northern Finland 1966 Birth Cohort), in which individuals were followed up prospectively until the age of 31 years. The information on allergic symptoms, verified by skin-prick tests and comprising data of 5518 individuals, was used to ascertain the presence of atopy. Depression was assessed with the help of Hopkins' Symptom Checklist-25 and self-reported doctor-diagnosed depression. After adjusting for a father's social class, mother's parity, and place of residence, logistic regression analyses showed that the risk of developing depression increased in parallel with the increasing severity of depression and, when compared with nonatopic subjects, was 3.0 to 4.7-fold up in atopic females and statistically significant. In atopic males, the association between atopy and depression was statistically significant only in the highest depression scores, the odds ratio being 6.3-fold. The results indicate that females suffering from atopic diseases might possess an elevated risk of developing depression already during early adulthood. In males, the association between these two disorders is evident only among the most severe manifestations of depression. Possible background theories, that is, genetic abnormalities in serotonin metabolism, HPA-axis dysfunction, and histamine theory are discussed.