Portraits of a Y-family DNA polymerase.
Portraits of a Y-family DNA polymerase.
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Y 家族 DNA 聚合酶的肖像。
DOI：
10.1016/j.febslet.2004.11.047
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发表时间：
2005
期刊：
影响因子：
3.5
通讯作者：
Yang,Wei
中科院分区：
文献类型：
--
作者：
Yang,Wei
DNA聚合酶Y家族的成员催化模板依赖的DNA合成，但与其他已知的DNA聚合酶没有序列同源性。Y-家族聚合酶在复制正常DNA时表现出高错误率和低加工率，但能够合成与受损模板相反的DNA。在过去的三年里，人们对这一聚合酶家族有了很多了解，包括测定了十几个具有不同底物的晶体结构。在这篇简短的综述中，我将对Y家族DNA聚合酶的生化性质和结构特征进行综述。
Members of the Y-family of DNA polymerases catalyze template-dependent DNA synthesis but share no sequence homology with other known DNA polymerases. Y-family polymerases exhibit high error rates and low processivity when copying normal DNA but are able to synthesize DNA opposite damaged templates. In the past three years, much has been learned about this family of polymerases including determination of more than a dozen crystal structures with various substrates. In this short review, I will summarize the biochemical properties and structural features of Y-family DNA polymerases.