Effects of anesthesia on efferent-mediated adaptation of the DPOAE
Effects of anesthesia on efferent-mediated adaptation of the DPOAE
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DOI：
10.1007/s101620020044
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发表时间：
2002-09-01
期刊：
影响因子：
--
通讯作者：
Brown, MC
中科院分区：
文献类型：
--
作者：
Boyev, KP;Liberman, MC;Brown, MC
由于初级音调引发的内侧橄榄耳蜗 (MOC) 活动的反馈效应，失真产物耳声发射 (DPOAE) 在初级音调出现后进行适应，时间常数类似于 100 毫秒。我们在豚鼠麻醉诱导之前和之后追踪 DPOAE 后适应，作为 MOC 反射强度的指标。该物种最常用的巴比妥类/精神安定药麻醉明显削弱了反射强度。 MOC 反射比捏脚趾或惊吓反射恢复得更慢，与一般活动能力的恢复相关性更好。当评估单独的麻醉剂时，巴比妥类（戊巴比妥）显着减弱 MOC 反射强度，而芬太尼。或氟哌利多没有。这些结果表明，之前使用麻醉制剂的研究可能低估了 OC 通路中声音诱发反应的强度。
Distortion product otoacoustic emissions (DPOAE) adapt after primary tone onset, with an similar to100 ms time constant, due to feedback effects of medial olivo-cochlear (MOC) activity elicited by the primary tones. We tracked DPOAE postonset adaptation as a metric of MOC reflex strength, before during and after induction of anesthesia in guinea pigs. Reflex strength was significantly diminished by the barbiturate/neuroleptic anesthesia most commonly used in this species. The MOC reflex recovered more slowly than toe-pinch or startle reflexes, correlating better with recovery of general mobility. When individual anesthetic agents were assessed, the barbiturate (pentobarbital) significantly diminished MOC reflex strength, whereas fentanyl. or droperidol did not. These results suggest that previous studies using anesthetized preparations may have underestimated the magnitude of sound-evoked responses in the OC pathway.