PET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depression.
PET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depression.
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DOI：
10.1176/ajp.145.8.937
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发表时间：
1988-08
期刊：
影响因子：
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通讯作者：
H. Mayberg;R. Robinson;D. Wong;Parikh Rm;P. Bolduc;S. Starkstein;T. Price;R. Dannals;J. Links;A. Wilson
中科院分区：
文献类型：
--
作者：
H. Mayberg;R. Robinson;D. Wong;Parikh Rm;P. Bolduc;S. Starkstein;T. Price;R. Dannals;J. Links;A. Wilson
损伤后超过1年的右半球卒中患者（N = 9）的（3-N-[11 C]甲基）螺哌隆皮质结合率高于左半球卒中患者（N = 8）或正常对照受试者（N = 17）。较高的S2 - 5-羟色胺受体结合发生在右顶叶和颞叶皮质的未受伤区域。同侧对侧皮质的结合率与左颞叶皮质抑郁评分的严重程度呈显著负相关。这些发现表明，大脑的生化反应可能会有所不同，这取决于哪个半球受伤，一些抑郁症可能是中风后未能上调5-羟色胺受体的结果。
Patients with right-hemisphere strokes (N = 9) more than 1 year after injury had greater cortical binding of (3-N-[11C]methyl)spiperone than a similar group of patients with left-hemisphere strokes (N = 8) or normal control subjects (N = 17). The higher S2 serotonin receptor binding occurred in uninjured regions of the right parietal and temporal cortex. The ratio of binding in the ipsilateral to contralateral cortex showed a significant negative correlation with severity of depression scores in the left temporal cortex. These findings suggest that the biochemical response of the brain may be different depending on which hemisphere is injured and that some depressions may be a consequence of the failure to upregulate serotonin receptors after stroke.