Shared transmission of eating disorders and anxiety disorders
Shared transmission of eating disorders and anxiety disorders
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DOI：
10.1002/eat.20168
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发表时间：
2005-09-01
影响因子：
5.5
通讯作者：
Iacono, WG
中科院分区：
文献类型：
--
作者：
Keel, PK;Klump, KL;Iacono, WG
目的：进食障碍与情绪、焦虑和物质使用障碍有较高的共患率。利用明尼苏达州双胞胎家庭研究(MTFS)中的双胞胎，我们检验了进食病理和这些疾病之间的共病和共同传播。方法：女性双胞胎(N=672)，年龄16-18岁，完成结构化的临床访谈，评估神经性厌食症和神经性暴食症(如第4版所述)。精神疾病诊断和统计手册[DSM-IV；美国精神病学协会，1994])以及情绪、焦虑和药物使用障碍(如第三次修订版所述)。《精神疾病诊断和统计手册》(DSM-III-R))。结果：进食障碍与严重的抑郁症、焦虑症和尼古丁依赖之间存在显著的共病。在进食障碍的MZ双胞胎中(n=14)，与对照组相比，不进食障碍的双胞胎患焦虑症的风险增加。同样，在与焦虑症不一致的MZ双胞胎中(n=52)，与对照组相比，非焦虑症的双胞胎患进食障碍的风险更高。讨论：研究结果支持进食障碍和焦虑症之间的共同传播。然而，这种共同素质的性质仍不清楚。(C)2005年，由威利期刊公司出版。
Objective: Eating disorders have high comorbidity with mood, anxiety, and substance use disorders. Using twins from the population-hased Minnesota Twin Family Study (MTFS), we examined comorbidity and shared transmission between eating pathology and these disorders.Method: Female twins (N = 672), ages 16-18years, completed structured clinical interviews assessing anorexia nervosa and bulimia nervosa (as described in the 4th ed. of the Diagnostic and Statistical Manual of Mental Disorders [DSM-IV; American Psychiatric Association, 1994]), as well as mood, anxiety, and substance use disorders (as described in the 3rd Rev. ed. of the Diagnostic and Statistical Manual of Mental Disorders [DSM-III-R]). Shared transmission was examined using a discordant monozygotic (MZ) twin design.Results: Significant comorbidity was found between eating disorders and major depression, anxiety disorders, and nicotine dependence. Within MZ twin pairs discordant for eating disorders (n = 14), non-eating-disordered cotwins demonstrated increased risk for anxiety disorders compared with controls. Similarly, within MZ twin pairs discordant for anxiety disorders (n = 52), non-anxiety-disordered cotwins demonstrated increased risk for eating disorders compared with controls.Discussion: Findings support shared transmission between eating disorders and anxiety disorders. However, the nature of this shared diathesis remains unknown. (c) 2005 by Wiley Periodicals, Inc.