TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality:: the Atherosclerosis Risk in Communities (ARIC) study
TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality:: the Atherosclerosis Risk in Communities (ARIC) study
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DOI：
10.1007/s00125-008-1004-1
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发表时间：
2008-06-01
期刊：
影响因子：
8.2
通讯作者：
Boerwinkle, E.
中科院分区：
文献类型：
--
作者：
Bielinski, S. J.;Pankow, J. S.;Boerwinkle, E.
目的/假设我们假设TCF 7 L2单核苷酸多态性（SNP）与心血管疾病（CVD）相关，并且这种相关性在糖尿病和非糖尿病人群中不同。方法我们的分析包括来自动脉粥样硬化风险社区研究的黑人和白色参与者，他们在基线时没有流行的CVD，并且已经进行了rs7903146，rs 12255372，rs7901695、rs 11196205和rs7895340（n= 13，369）。采用考克斯比例风险回归分析多态性与事件发生的关系;结果TCF 7 L2单核苷酸多态性与冠心病、缺血性脑卒中、心血管疾病、在整个队列中或按种族分层时，普遍的外周动脉疾病（PAD）或全因死亡率。结论/解释在整个队列中，TCF 7 L2 SNPs与CVD事件、全因死亡率或PAD患病率无关。这一结果表明，与rs7903146基因型相关的健康风险增加是糖尿病特有的。
Aims/hypothesis We hypothesised that TCF7L2 single nucleotide polymorphisms (SNPs) are associated with cardiovascular disease (CVD) and that the associations differ in diabetic and non-diabetic persons.Methods Our analysis included black and white participants from the Atherosclerosis Risk in Communities study who were free of prevalent CVD at baseline and had been genotyped for rs7903146, rs12255372, rs7901695, rs11196205 and rs7895340 (n=13,369). Cox proportional hazard regression was used to estimate the associations between polymorphisms and incident events; logistic and linear regression were used for associations with baseline risk factor levels.Results TCF7L2 SNPs were not significantly associated with incident coronary heart disease, ischaemic stroke, CVD, prevalent peripheral artery disease (PAD) or all-cause mortality in the full cohort or when stratified by race.Conclusions/interpretation In the whole cohort, TCF7L2 SNPs were not associated with incident CVD, all-cause mortality or prevalent PAD. This result suggests that the increased health risk associated with rs7903146 genotype is specific to diabetes.