Nucleobase modifications in peptide nucleic acids.
Nucleobase modifications in peptide nucleic acids.
复制标题
肽核酸中的核碱基修饰。
DOI：
10.2174/156802607780487795
复制
发表时间：
2007
影响因子：
3.4
通讯作者：
R. Hudson
中科院分区：
文献类型：
--
作者：
F. Wojciechowski;R. Hudson
肽核酸（PNA）是一种寡核苷酸模拟物，最初设计在重复的N-（2-氨基乙基）甘氨酸聚酰胺主链上，其核碱基杂环通过亚甲基羰基连接到-氨基。这些分子与DNA或RNA具有显著的杂交特性，形成高稳定性的复合物，尽管与天然核酸存在很大的结构差异，但具有良好的序列辨别能力。自从PNA的披露以来，一个充满活力的研究团体对聚酰胺基核酸类似物的化学和应用感兴趣。这导致了各种改性聚酰胺核酸的合成和评价。本报告的重点是对氨基乙基甘氨酸（aeg） PNA中的核碱基修饰进行全面回顾，并在适当的情况下参考DNA或RNA中的相同修饰。
Peptide nucleic acid (PNA) is an oligonucleotide mimic originally designed upon a repeating N-(2-aminoethyl)glycine polyamide backbone to which nucleobase heterocycles are attached through a methylene carbonyl linkage to the alpha-amino group. These molecules possess remarkable hybridization properties with DNA or RNA forming complexes with high stability and with excellent sequence discrimination despite the substantial structural divergence from natural nucleic acids. Since the disclosure of PNA, a vibrant research community with interest in the chemistry and applications of polyamide-based nucleic acid analogs has developed. This has led to the synthesis and evaluation of a wide variety of modified polyamide nucleic acids. The focus of this report is a comprehensive review of nucleobase modifications in aminoethylglycine (aeg) PNA with reference, where appropriate, to the same modification in DNA or RNA.