AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?
AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?
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DOI：
10.2174/1389450116666150416120559
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发表时间：
2016-05
影响因子：
3.2
通讯作者：
D. Moreira;R. Silvestre;A. Cordeiro-da-Silva;J. Estaquier;M. Foretz;B. Viollet
中科院分区：
文献类型：
--
作者：
D. Moreira;R. Silvestre;A. Cordeiro-da-Silva;J. Estaquier;M. Foretz;B. Viollet
已知细胞内病原体操纵宿主细胞调节途径以建立其生长和存活的最佳环境。病原体通过主动机制劫持宿主细胞的代谢，获取已有的营养和能量储备。细胞能量传感器AMP激活的蛋白激酶（AMPK）在调节细胞能量稳态中的作用已被充分证明。在这里，我们强调了最新的进展，表明AMPK信号在病原体-宿主相互作用的重要性。病原体通过多种机制与AMPK相互作用，旨在重新编程宿主细胞代谢以使其自身受益。AMPK活性的刺激提供了一个有效的过程，以快速适应病原体代谢的主要营养变化，经常遇到在感染的不同阶段。然而，AMPK的抑制也被病原体用来操纵先天宿主反应，表明AMPK似乎与限制病原体感染有关。我们还记录了药理学AMPK调节剂对病原体增殖和存活的影响。这篇综述阐明了复杂的病原体-AMPK相互作用，可用于开发新的抗病原体疗法。
Intracellular pathogens are known to manipulate host cell regulatory pathways to establish an optimal environment for their growth and survival. Pathogens employ active mechanisms to hijack host cell metabolism and acquire existing nutrient and energy store. The role of the cellular energy sensor AMP-activated protein kinase (AMPK) in the regulation of cellular energy homeostasis is well documented. Here, we highlight recent advances showing the importance of AMPK signaling in pathogen-host interactions. Pathogens interact with AMPK by a variety of mechanisms aimed at reprogramming host cell metabolism to their own benefit. Stimulation of AMPK activity provides an efficient process to rapidly adapt pathogen metabolism to the major nutritional changes often encountered during the different phases of infection. However, inhibition of AMPK is also used by pathogens to manipulate innate host response, indicating that AMPK appears relevant to restriction of pathogen infection. We also document the effects of pharmacological AMPK modulators on pathogen proliferation and survival. This review illustrates intricate pathogen-AMPK interactions that may be exploited to the development of novel anti-pathogen therapies.