The emergence of the Middle East respiratory syndrome coronavirus.
The emergence of the Middle East respiratory syndrome coronavirus.
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DOI：
10.1111/2049-632x.12166
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发表时间：
2014-07
影响因子：
3.3
通讯作者：
Munster VJ
中科院分区：
文献类型：
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作者：
Milne-Price S;Miazgowicz KL;Munster VJ
2012年9月20日，一名沙特阿拉伯医生在ProMED‐mail上报告从一名肺炎患者身上分离出一种新型冠状病毒。几天之内，在伦敦一家医院接受重症监护的一名卡塔尔患者身上检测到了同样的病毒，这种情况让人想起了2002年航空旅行在严重急性呼吸道综合征冠状病毒（SARS‐CoV）传播中所扮演的角色。SARS冠状病毒起源于中国广东省，在6个月后被控制之前，影响了26个国家的8000多名患者。在这种新型冠状病毒-中东呼吸综合征冠状病毒（MERS-CoV）出现一年多后，它已造成178例实验室确诊病例和76例死亡。十年内第二种高致病性冠状病毒的出现凸显了协调全球应对的重要性，包括水库监测，基础和应用研究计划的高遏制能力，以及可靠的通信途径，以确保遏制疫情。在这里，我们回顾了关于新型冠状病毒MERS-CoV的流行病学，生态学，分子生物学，临床特征和干预策略的知识现状。及时和新出现的传染病的优秀审查。
On September 20, 2012, a Saudi Arabian physician reported the isolation of a novel coronavirus from a patient with pneumonia on ProMED‐mail. Within a few days, the same virus was detected in a Qatari patient receiving intensive care in a London hospital, a situation reminiscent of the role air travel played in the spread of severe acute respiratory syndrome coronavirus (SARS‐CoV) in 2002. SARS‐CoV originated in China's Guangdong Province and affected more than 8000 patients in 26 countries before it was contained 6 months later. Over a year after the emergence of this novel coronavirus – Middle East respiratory syndrome coronavirus (MERS‐CoV) – it has caused 178 laboratory‐confirmed cases and 76 deaths. The emergence of a second highly pathogenic coronavirus within a decade highlights the importance of a coordinated global response incorporating reservoir surveillance, high‐containment capacity with fundamental and applied research programs, and dependable communication pathways to ensure outbreak containment. Here, we review the current state of knowledge on the epidemiology, ecology, molecular biology, clinical features, and intervention strategies of the novel coronavirus, MERS‐CoV. Excellent review on timely and newly emerging infectious diseases.