Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation
Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation
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DOI：
10.1101/gad.178780.111
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发表时间：
2011-12-15
影响因子：
10.5
通讯作者：
Lodish, Harvey F.
中科院分区：
文献类型：
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作者：
Hu, Wenqian;Yuan, Bingbing;Lodish, Harvey F.
长链非编码RNA（lncRNA）在正常和病理条件下均存在差异表达，这意味着它们可能发挥重要的生物学功能。在这里，我们研究了lncRNA在红细胞生成过程中的表达，并确定了红细胞特异性lncRNA与抗凋亡活性。这种lncRNA的抑制阻断红细胞分化并促进细胞凋亡。相反，这种lncRNA的异位表达可以抑制小鼠红系细胞的凋亡。这种lncRNA抑制Pycard（一种促凋亡基因）的表达，部分解释了程序性细胞死亡的抑制。这些发现揭示了一种新的lncRNA对细胞分化和凋亡的调节层。
Long noncoding RNAs (lncRNAs) are differentially expressed under both normal and pathological conditions, implying that they may play important biological functions. Here we examined the expression of lncRNAs during erythropoiesis and identified an erythroid-specific lncRNA with anti-apoptotic activity. Inhibition of this lncRNA blocks erythroid differentiation and promotes apoptosis. Conversely, ectopic expression of this lncRNA can inhibit apoptosis in mouse erythroid cells. This lncRNA represses expression of Pycard, a proapoptotic gene, explaining in part the inhibition of programmed cell death. These findings reveal a novel layer of regulation of cell differentiation and apoptosis by a lncRNA.