Ca(2+)-cyclic AMP interactions in sustained cellular responses.
Ca(2+)-cyclic AMP interactions in sustained cellular responses.
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DOI：
10.1002/9780470514207.ch7
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
H. Rasmussen;C. Isales;S. Ganesan;R. Calle;W. Zawalich
中科院分区：
文献类型：
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作者：
H. Rasmussen;C. Isales;S. Ganesan;R. Calle;W. Zawalich
早在1970年，环磷酸腺苷(CAMP)和钙信使系统经常相互作用来调节细胞的反应。过去20年的工作极大地扩展了我们对这些相互作用的了解，并表明这些信号系统以复杂的方式相互作用，调节持续的细胞反应，如醛固酮分泌、平滑肌收缩和胰岛素分泌。后一种系统之所以被详细考虑，是因为它说明了几种类型的相互作用，包括积极和消极的，这有助于确定β细胞对生理刺激的正常反应，以及分泌模式的异常如何作为信使系统长期刺激的结果而发展。
As early as 1970 it was apparent that the cyclic AMP (cAMP) and Ca2+ messenger systems often interact to regulate cellular responses. Work over the past 20 years has greatly expanded our knowledge of these interactions, and has shown that these signalling systems interact in complex ways to regulate sustained cellular responses such as aldosterone secretion, smooth muscle contraction and insulin secretion. The latter system is considered in detail because it illustrates several types of interactions, both positive and negative, which help to determine the normal response of beta-cells to physiological stimuli, and how abnormalities in secretory patterns can develop as a consequence of the prolonged stimulation of a messenger system.