Dehydrooligopeptides. XVII. Practical Syntheses of All of the Diastereomers of N,N-Protected 2,3-Diaminobutanoic Acids from L- and D-Threonine Derivatives
Dehydrooligopeptides. XVII. Practical Syntheses of All of the Diastereomers of N,N-Protected 2,3-Diaminobutanoic Acids from L- and D-Threonine Derivatives
复制标题
脱氢寡肽。
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
C. Shin
中科院分区：
文献类型：
--
作者：
Yutaka Nakamura*;M. Hirai;K. Tamotsu;Y. Yonezawa;C. Shin
合成了一些多肽抗生素和毒素中发现的所有2，3-二氨基丁酸的非对映异构体。这四种异构体主要通过两条途径得到，包括L或D-苏氨酸衍生物的β-取代基的SN2反转。考察了SN2转化的各种保护基团和有效的亲核试剂。
Syntheses of all of the diastereomers of 2,3-diaminobutanoic acids, found in some peptide antibiotics and toxins, were accomplished. The four isomers were derived mainly through two pathways including SN2 inversions of the β-substituent of L- or D-threonine derivatives. The various protecting groups and effective nucleophiles for the SN2 inversion were examined.