Vasopressin potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture.
Vasopressin potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture.
复制标题
加压素可增强培养的大鼠垂体前叶细胞中由促肾上腺皮质激素释放因子 (CRF) 诱导的环 AMP 积累和 ACTH 释放。
DOI：
10.1210/endo-111-5-1752
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发表时间：
1982
期刊：
影响因子：
4.8
通讯作者：
F. Labrie
中科院分区：
文献类型：
--
作者：
Vincent Giguère;F. Labrie
激动剂[Asu11，6Arg8]加压素(VAS-A)使CRF对培养的大鼠垂体前叶细胞释放ACTH的刺激作用增加2倍。尽管加压素激动剂单独对cAMP水平没有影响，但它导致CRF诱导的cAMP积聚在所有时间间隔和CRF浓度下增加2倍。目前的数据表明，加压素对CRF诱导的ACTH释放的增强作用是通过平行改变细胞内cAMP水平来实现的。
The agonist,[Asu11,6Arg8]vasopressin (VAS-A), causes a 2-fold increase in the stimulatory effect of CRF on ACTH release in rat anterior pituitary cells in culture. Although the vasopressin agonist alone has no effect on cyclic AMP levels, it causes a 2-fold increase in CRF-induced cyclic AMP accumulation at all time intervals and concentrations of CRF. The present data show that the potentiating effect of vasopressin on CRF-induced ACTH release is achieved through parallel changes of intracellular cyclic AMP levels