PSORIASIS IN AUSTRALIAN TWINS
PSORIASIS IN AUSTRALIAN TWINS
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DOI：
10.1016/0190-9622(93)70206-9
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发表时间：
1993-09-01
影响因子：
13.8
通讯作者：
MARTIN, NG
中科院分区：
文献类型：
--
作者：
DUFFY, DL;SPELMAN, LS;MARTIN, NG
背景资料：在北方欧洲和美国的双生子和家系研究中发现银屑病的发生受到强烈的遗传控制。目的：我们的目的是评估澳大利亚人群银屑病的累积发病率和遗传度。从3808对澳大利亚双胞胎中收到的筛查问卷报告银屑病邮寄一个详细的工具，旨在验证诊断，辅以电话采访和检查的医疗记录。在160名筛查呈阳性的受试者中，只有94名被证实患有银屑病。在30至60岁的受试者中，确诊银屑病的累积发生率为2%。确诊银屑病的同卵双胞胎病例一致性为35%（34对中的12对），异卵双胞胎一致性为12%（43对中的5对），估计遗传率为80%，与先前三项双胞胎研究的遗传再分析结果相似。银屑病不一致的双胞胎病例对照分析发现，没有证据表明酒精或咖啡摄入量的影响，超重，出生体重，或个性的起源psorias.Conclusion：银屑病的发生在澳大利亚人口是高度遗传的，但同卵双胞胎往往是不一致的，负责发病的因素，在一个双胞胎，而不是其他尚不清楚。
Background: Occurrence of psoriasis has been found to be strongly genetically controlled in Northern European and U.S. twin and family studies.Objective: Our purpose was to assess cumulative incidence and heritability of psoriasis in the Australian population.Methods. Australian twins reporting psoriasis on a screening questionnaire received from 3808 pairs were mailed a detailed instrument designed to validate the diagnosis, supplemented by telephone interview and examination of medical records.Results. Only 94 of 160 subjects who screened positive were confirmed to have psoriasis. The cumulative incidence of confirmed psoriasis was 2% in 30- to 60-year-old subjects. The monozygotic twin casewise concordance for confirmed psoriasis was 35% (12 of 34 pairs), and the dizygotic twin concordance 12% (5 of 43 pairs), giving an estimated heritability of 80%, was similar to that found in a genetic reanalysis of three previous twin studies. A case-control analysis of psoriasis-discordant twin pairs found no evidence for influences of alcohol or coffee intake, overweight, birth weight, or personality in the origin of psoriasis.Conclusion: Occurrence of psoriasis in the Australian population is highly heritable, but identical twins are often discordant; the factor responsible for the onset of disease in one twin and not the other is unclear.