Phage lambda has an analog of Escherichia coli recO, recR and recF genes.
Phage lambda has an analog of Escherichia coli recO, recR and recF genes.
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λ噬菌体具有大肠杆菌recO、recR和recF基因的类似物。
DOI：
10.1093/genetics/130.1.7
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发表时间：
1992
期刊：
影响因子：
3.3
通讯作者：
Stahl,FW
中科院分区：
文献类型：
--
作者：
Sawitzke,JA;Stahl,FW
RecF途径在突变的recBC、sbcB和sbcC大肠杆菌中催化广义重组。这种偶联重组途径需要recA、recF、recJ、recN、recO、recQ、recR、ruvA、ruvB和ruvC基因参与。相比之下，lambda突变体自身重组基因int、red alpha和red beta只需要recA和recJ基因就能在recBC sbcB sbcC细胞中有效重组。在lambda的ninR区域中缺失一个开放阅读框会导致recO、recR和recF在recBC sbcB sbcC突变细胞中重组的额外需求。该功能被称为orf，用于recO-， recR-和RecF -样功能，主要是RecF通路特异性的。
The RecF pathway catalyzes generalized recombination in Escherichia coli that is mutant for recBC, sbcB and sbcC. This pathway operating on conjugational recombination requires the recA, recF, recJ, recN, recO, recQ, recR, ruvA, ruvB and ruvC genes. In contrast, lambda mutant for its own recombination genes, int, red alpha and red beta, requires only the recA and recJ genes to recombine efficiently in recBC sbcB sbcC cells. Deletion of an open reading frame in the ninR region of lambda results in an additional requirement for recO, recR and recF in order to recombine in recBC sbcB sbcC mutant cells. This function, designated orf for recO-, recR- and recF-like function, is largely RecF pathway specific.