Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients
Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients
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DOI：
10.2217/14622416.9.11.1595
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发表时间：
2008-11-01
期刊：
影响因子：
2.1
通讯作者：
Hauser, Joanna
中科院分区：
文献类型：
--
作者：
Dmitrzak-Weglarz, Monika;Rybakowski, Janusz K.;Hauser, Joanna
双相情感障碍的神经可塑性假说表明 BDNF/Trk 信号通路与这种疾病的发病机制以及锂等情绪稳定剂的治疗有关。本文描述了双向情感障碍中锂预防反应与两个功能相关基因 BDNF 和 NTRK2 多态性之间的关系。在 108 名双相情感障碍患者中进行了 BDNF 基因的 4 个 SNP（rs2030324、rs988748、rs6265 [Val66Met] 和 rs2203877）和 3 个 NTRK2 基因（rs1187326、rs2289656、rs1187327）的分析，这些患者被归类为优秀反应者(23%), 对锂有部分反应者（51%）和无反应者（26%）。 BDNF 基因的 C/G (rs988748) 和 G/A (rs6265) 多态性与一定程度的预防性锂反应存在关联。 NTRK2 基因的多态性与锂反应无关，也与 BDNF 和 NTRK2 基因的相互作用无关。
The neuroplasticity hypothesis of bipolar disorder indicates that the BDNF/Trk signaling pathway is associated with the pathogenesis of this illness and treatment with mood stabilizers, such as lithium. This paper describes a relationship between response to lithium prophylaxis and polymorphisms of two functionally connected genes: BDNF and NTRK2, in bipolar illness. Analyses of four SNPs of the BDNF gene (rs2030324, rs988748, rs6265 [Val66Met] and rs2203877) and three of the NTRK2 gene (rs1187326, rs2289656, rs1187327) were performed in the 108 bipolar patients, classified as excellent responders (23%), partial responders (51%) and nonresponders (26%) to lithium. An association of C/G (rs988748) and G/A (rs6265) polymorphisms of the BDNF gene with a degree of prophylactic lithium response were found. No association with lithium response was revealed with the polymorphism of NTRK2 gene, neither with interaction of BDNF and NTRK2 genes.