Citicoline-liposome/polyurethane composite scaffolds regulate the inflammatory response of microglia to promote nerve regeneration
Citicoline-liposome/polyurethane composite scaffolds regulate the inflammatory response of microglia to promote nerve regeneration
复制标题
胞二磷胆碱-脂质体/聚氨酯复合支架调节小胶质细胞炎症反应促进神经再生
DOI：
10.1007/s10853-021-06628-0
复制
发表时间：
2022
影响因子：
4.5
通讯作者：
Jiehua Li
中科院分区：
文献类型：
--
作者：
Jingjing Lin;Xingying Song;Hang Yin;Nijia Song;Yanchao Wang;Zhen Li;Feng Luo;Hong Tan;Xueling He;Jiehua Li
调节中枢神经元周围的免疫微环境是一个难题。为了解决这一关键问题，载药支架是一种很有前途的方法，它可以直接将药物释放到周围细胞，而忽略血脑屏障和血髓屏障的影响。小胶质细胞是中枢神经系统中基本的先天性免疫哨兵，通常在神经炎症期间被激活。胞二磷胆碱（Citicoline，CDPC）是一种神经保护剂，用于中枢神经系统疾病的治疗。为克服胞二磷胆碱（CDPC）在中枢神经系统（CNS）的低摄取效率和改善其免疫微环境，本研究制备了CDPC-脂质体杂化和CDPC直接共混的水性聚氨酯支架双局部给药系统。说明CDPC-脂质体复合支架更有利于抑制小胶质细胞的炎症反应，促进轴突伸长，在神经修复领域呈现一定的前景。
Regulating the immune microenvironment around the central neurons is a difficult problem. To address this critical matter, drug-loading scaffolds are promising ways of releasing drugs directly to the surrounding cells and ignoring the influence of blood–brain barrier and blood–medullary barrier. Microglia are fundamental innate immune sentinels in the central nervous system, usually activated during neuroinflammation. Citicoline (CDPC), a neuroprotective agent on secondary injuries, is used in clinical treatment of central nervous system diseases. To overcome low efficiency of CDPC uptake and improve immune microenvironment of CDPC in central nervous system (CNS), in this work, double local drug delivery systems, hybrid CDPC–liposome and CDPC blending directly waterborne polyurethane scaffolds, were prepared. It shows that CDPC–liposome composite scaffolds are more conducive to inhibit the inflammatory response of microglia and promote axon elongation, which presents a certain prospect in the field of nerve repair.Graphical abstract