Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: The Ely study 1990-2000
Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: The Ely study 1990-2000
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DOI：
10.1111/j.1464-5491.2007.02068.x
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发表时间：
2007-02-01
影响因子：
3.5
通讯作者：
Wareham, N. J.
中科院分区：
文献类型：
--
作者：
Forouhi, N. G.;Luan, J.;Wareham, N. J.
目的 确定 2 型糖尿病的发病率，并检查空腹血糖受损 (IFG) 的不同切点对糖尿病发病率的影响。 方法 对 1040 名 40-69 岁的基线非糖尿病成年人进行基于人群的纵向研究（1990-2000 年），包括临床、人体测量和生化测量，包括口服葡萄糖耐量试验 (OGTT)。基线血糖状态定义为正常血糖< 5.6、IFG-较低5.6-6.0和IFG-原始6.1-6.9 mmol/l。全IFG组的空腹血糖值为5.6-6.9mmol/l。结果糖尿病的10年累积发病率为每1000人年7.3人。血糖正常、IFG 较低和 IFG 原始患者的糖尿病发病率分别为每 1000 人年 2.4 例 [95% 置信区间 (CI) 1.2, 4.8]、6.2 (4.0, 9.8) 和 17.5 (12.5, 24.5)。与血糖正常相比，年龄/性别调整后的糖尿病发生风险[风险比 (HR) 和 95% CI] 在 IFG 原始类别中最大 (HR 6.9; 3.1, 15.2)，在 IFG 较低类别 (HR 2.5; 1.1, 5.7) 和全 IFG 类别 (HR 4.1; 1.9, 1.9) 中增加程度较小。 8.7）。调整混杂因素后，相关性的大小和方向仍然存在，对于 IFG 较低、IFG 原始和全 IFG 类别，关联的程度和方向仍然存在，HR 分别为 1.9、4.4 和 2.9。 结论 糖尿病发病率与 IFG 定义为空腹血糖在 6.1 至 6.9 mmol/l 之间的相关性比与较低类别 5.6-6.0 mmol/l 或整个范围的空腹血糖相关性更强。 5.6-6.9 毫摩尔/升。未来的研究应该检查 IFG 与心血管结局的关系，但对于糖尿病风险，我们的研究支持使用 6.1 mmol/l 的 IFG 临界点。
Aim To determine the incidence of Type 2 diabetes and to examine the effect of different cut-points for impaired fasting glucose (IFG) on diabetes incidence.Methods Population-based longitudinal study (1990-2000) with clinical, anthropometric and biochemical measurements, including an oral glucose tolerance test (OGTT), in 1040 non-diabetic adults aged 40-69 years at baseline. Baseline glucose status was defined as normoglycaemia < 5.6, IFG-lower 5.6-6.0 and IFG-original 6.1-6.9 mmol/l. The all-IFG group included fasting glucose values of 5.6-6.9 mmol/l.Results The 10-year cumulative incidence of diabetes was 7.3 per 1000 person-years. Diabetes incidence was 2.4 [95% confidence interval (CI) 1.2, 4.8], 6.2 (4.0, 9.8) and 17.5 (12.5, 24.5) per 1000 person-years in those with normoglycaemia, IFG-lower and IFG-original, respectively. Compared with normoglycaemia, the age/sex-adjusted risk [hazard ratio (HR) and 95% CI] for incident diabetes was greatest in the IFG-original category (HR 6.9; 3.1, 15.2) and increased to a lesser degree in the IFG-lower (HR 2.5; 1.1, 5.7) and all-IFG categories (HR 4.1; 1.9, 8.7). When adjusted for confounding factors, the magnitude and direction of associations persisted, with HR 1.9, 4.4 and 2.9, for the categories IFG-lower, IFG-original and all-IFG, respectively.Conclusions Diabetes incidence is more strongly related to IFG defined as fasting glucose between 6.1 and 6.9 mmol/l than to the lower category of 5.6-6.0 mmol/l, or entire range of 5.6-6.9 mmol/l. Future studies should examine the association of IFG with cardiovascular outcomes, but for diabetes risk our study supports the use of the IFG cut-point at 6.1 mmol/l.