Reducing the cost of post-exposure rabies prophylaxis: efficacy of 0.1 ml PCEC rabies vaccine administered intradermally using the Thai Red Cross post-exposure regimen in patients severely exposed to laboratory-confirmed rabid animals
Reducing the cost of post-exposure rabies prophylaxis: efficacy of 0.1 ml PCEC rabies vaccine administered intradermally using the Thai Red Cross post-exposure regimen in patients severely exposed to laboratory-confirmed rabid animals
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DOI：
10.1016/j.vaccine.2004.09.027
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发表时间：
2005-02-25
期刊：
影响因子：
5.5
通讯作者：
Malerczyk, C
中科院分区：
文献类型：
--
作者：
Quiambao, BP;Dimaano, EM;Malerczyk, C
与传统的五剂埃森方案相比，根据泰国红十字会 (TRC) 方案，以 0.1 毫升皮内注射的纯化鸡胚细胞狂犬病疫苗 (PCECV) 可以将 PEP 成本降低高达 84%。使用 TRC 方案确认 0.1 ml PCECV 的功效。在菲律宾的两个咬伤转诊中心，对 113 名患有狂犬病确诊动物的 III 类暴露的患者进行了一项临床试验。接触后一年内每月对患者进行监测。 PCECV 耐受性良好，没有发生与疫苗相关的严重不良事件，所有患者在初次接触后 1 年后均存活。 (C) 2004 Elsevier Ltd. 保留所有权利。
Purified chick embryo cell rabies vaccine (PCECV) administered as 0.1 ml intradermally according to the Thai Red Cross (TRC) regimen could reduce the cost of PEP by up to 84% when compared to the traditional five-dose Essen regimen. To confirm the efficacy of 0.1 ml of PCECV using the TRC regimen. a clinical trial was conducted in 113 patients presenting with category III exposures from confirmed rabid animals at two bite referral centres in the Philippines. Patients were monitored monthly for 1 year after exposure. PCECV was well tolerated, no vaccine-related serious adverse events occurred and all patients were alive 1 year after their initial exposure. (C) 2004 Elsevier Ltd. All rights reserved.