D2 receptors in Huntington's disease: positron emission tomography findings and clinical correlates.
D2 receptors in Huntington's disease: positron emission tomography findings and clinical correlates.
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亨廷顿病中的 D2 受体：正电子发射断层扫描结果和临床相关性。
DOI：
10.1176/jnp.2.1.20
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Tune,LE
中科院分区：
文献类型：
--
作者：
Brandt,J;Folstein,SE;Wong,DF;Links,J;Dannals,RF;McDonnell-Sill,A;Starkstein,S;Anders,P;Strauss,ME;Tune,LE
在21例亨廷顿病（HD）患者和8例有发展亨廷顿病风险的个体中，研究了尾状核和壳核中多巴胺受体结合与神经和神经心理功能的关系。在HD患者的尾状核和壳核中发现[11 C] 3-N-甲基螺哌隆与多巴胺受体的相对结合显著减少。尾状核中的结合仅与快速编码和设置交替测试相关，而壳核中的结合仅与疾病持续时间相关。研究结果表明，亨廷顿病患者纹状体的萎缩性变化伴随着受体的改变。他们还支持以前的动物和人类研究表明，尾状核在认知中发挥更大的作用，而不是在运动功能。
The relationship of dopamine receptor binding in the caudate nucleus and the putamen to neurological and neuropsychological functioning was examined in 21 patients with Huntington's disease (HD) and eight individuals at risk of developing Huntington's disease. A significant reduction in relative binding of [11C] 3-N-methylspiperone to the dopamine receptor was found in both the caudate and putamen of HD patients. Binding in the caudate was correlated only with tests of rapid coding and set alternation, while binding in the putamen was correlated only with duration of illness. The findings indicate that the well-described atrophic changes in the striatum of Huntington's disease patients are accompanied by receptor alterations. They also support previous animal and human studies indicating that the caudate nucleus plays a larger role in cognition than in motor functions.