The PAS protein VIVID defines a clock-associated feedback loop that represses light input, modulates gating, and regulates clock resetting
The PAS protein VIVID defines a clock-associated feedback loop that represses light input, modulates gating, and regulates clock resetting
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DOI：
10.1016/s0092-8674(01)00232-x
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发表时间：
2001-02-09
期刊：
影响因子：
64.5
通讯作者：
Dunlap, JC
中科院分区：
文献类型：
--
作者：
Heintzen, C;Loros, JJ;Dunlap, JC
Vvd是一种调节脉孢菌光反应的基因，编码PAS/LOV蛋白超家族的一个新成员。VVD定义了一个与昼夜时钟相关的自动调节反馈环路，该环路影响光重置，通过连接输出和输入来调节输入的昼夜节律门控，并调节光适应。快速光诱导，VVD是光调节过程的早期抑制因子。此外，VVD是由时钟控制的；时钟门控VVD的光感应和时钟基因，因此相同的信号在早上产生更大的感应。VVD突变严重抑制门控，尤其是FRO，与VVD调制门控和相位正确重置反应一致。VVD零应变对光的相位响应曲线显示出明显的变化。因此，VVD虽然不是生物钟的一部分，但在脉孢子虫昼夜节律系统中起着重要的调节作用。
vvd, a gene regulating light responses in Neurospora, encodes a novel member of the PAS/LOV protein superfamily. VVD defines a circadian clock-associated autoregulatory feedback loop that influences light resetting, modulates circadian gating of input by connecting output and input, and regulates light adaptation. Rapidly light induced, vvd is an early repressor of light-regulated processes. Further, vvd is clock controlled; the clock gates light induction of vvd and the clock gene fro so identical signals yield greater induction in the morning. Mutation of vvd severely dampens gating, especially of fro, consistent with VVD modulating gating and phasing right-resetting responses. vvd null strains display distinct alterations in the phase-response curve to light. Thus VVD, although not part of the clock, contributes significantly to regulation within the Neurospora circadian system.