Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells
Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells
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DOI：
10.1248/cpb.52.935
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发表时间：
2004-08-01
影响因子：
1.7
通讯作者：
Kobayashi, M
中科院分区：
文献类型：
--
作者：
Aoki, S;Kong, D;Kobayashi, M
研究了一种新的倍半萜氨基醌- 5-epi-smenospongorine和9种已知的倍半萜醌/酚类化合物，作为诱导海绵体K562细胞向红母细胞分化的物质。这些化合物的构效关系研究表明，醌骨架和氨基在诱导K562细胞向红母细胞分化的过程中起着重要作用。
A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast.