New neurons follow the flow of cerebrospinal fluid in the adult brain
New neurons follow the flow of cerebrospinal fluid in the adult brain
复制标题
DOI：
10.1126/science.1119133
复制
发表时间：
2006-02-03
期刊：
影响因子：
56.9
通讯作者：
Alvarez-Buylla, A
中科院分区：
文献类型：
--
作者：
Sawamoto, K;Wichterle, H;Alvarez-Buylla, A
在成年人的大脑中，脑室下区的神经母细胞从侧脑室的瓦特迁移到嗅球。这些细胞如何在如此长的距离和复杂的领土上定位？在这里，我们表明，成神经细胞迁移平行脑脊液（CSF）的流动。室管膜纤毛的搏动是正常CSF流动、CSF引导分子的浓度梯度形成和成神经细胞的定向迁移所必需的。结果表明，极化上皮。细胞提供了重要的矢量信息，用于引导年轻的迁移神经元。
In the adult brain, neuroblasts born in the subventricular zone migrate from the watts of the lateral ventricles to the olfactory bulb. How do these cells orient over such a tong distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial. cells contribute important vectorial information-for guidance of young, migrating neurons.