Asymmetric Access to the Smallest Enolate Intermediate via Organocatalytic Activation of Acetic Ester
Asymmetric Access to the Smallest Enolate Intermediate via Organocatalytic Activation of Acetic Ester
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DOI：
10.1021/ol402877n
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发表时间：
2013-11-15
期刊：
影响因子：
5.2
通讯作者：
Chi, Yonggui Robin
中科院分区：
文献类型：
--
作者：
Chen, Shaojin;Hao, Lin;Chi, Yonggui Robin
本发明公开了一种NHC催化的乙酸酯活化以提供烯醇中间体。催化生成的三氮唑烯醇酸中间体作为双碳亲核剂与烯酮和α，β-不饱和亚胺进行高度的对映选择性反应，分别得到α-未取代的三角洲-内酯和内酰胺类化合物。
An NHC-catalyzed activation of acetic esters to afford enolate intermediates is disclosed. The catalytically generated triazolium enolate intermediates serve as two-carbon nucleophiles that undergo highly enantioselective reactions with enones and alpha,beta-unsaturated imines to give a-unsubstituted delta-lactones and lactams, respectively.