Coupling selectivity with sensitivity in an integrated chemosensor framework:: Design of a Hg2+-responsive probe, operating above 500 nm
Coupling selectivity with sensitivity in an integrated chemosensor framework:: Design of a Hg2+-responsive probe, operating above 500 nm
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DOI：
10.1021/ja0290779
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发表时间：
2003-03-26
影响因子：
15
通讯作者：
Soto, J
中科院分区：
文献类型：
--
作者：
Descalzo, AB;Martínez-Máñez, R;Soto, J
为了对水中的 Hg2+ 进行高选择性和灵敏的传感，实现了一种新的设计理念，其中通过发色团的电子特性放大了探针结合位点的选择性。这种吩恶嗪酮型传感器分子的分子结构通过氨基-酮共轭主链结合了两个潜在的配位位点。这些结构先决条件仅允许最优选的汞离子与二硫二氧杂单氮杂冠单元结合，而其他重金属离子、过渡金属离子和主族金属离子以及质子被捕获在酮基上，由于与探针的供体（Hg2+）或受体基团（其他阳离子）相互作用而引起相反的光谱效应。除了这些有利的特征之外，该探针在可见光谱范围内运行良好，并显示出相当强的摩尔吸收率以及荧光量子产率。
For the highly selective and sensitive sensing of Hg2+in water, a new design concept was realized where the selectivity of the probe's binding site is amplified by electronic properties of the chromophore. The molecular architecture of this phenoxazinone-type sensor molecule combines two potential coordination sites via an amino-keto conjugative backbone. These structural prerequisites allow only the most preferred mercuric ion to bind to the dithia dioxa monoaza crown unit, while other heavy, transition, and main group metal ions as well as protons are trapped at the keto group, inducing opposite spectral effects due to interaction with either the donor (Hg2+) or the acceptor group (other cations) of the probe. Besides these advantageous features, the probe operates well within the visible range of the spectrum and displays rather intense molar absorptivities as well as fluorescence quantum yields.