The growing lung: normal development, and the long-term effects of pre- and postnatal insults
The growing lung: normal development, and the long-term effects of pre- and postnatal insults
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不断生长的肺部：正常发育以及产前和产后损伤的长期影响
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
A. Bush
中科院分区：
文献类型：
--
作者：
M. Rosenthal;A. Bush
乍一看，成年医生可能会觉得宫内肺发育对他们来说并不重要。然而，矛盾的是，发育中的肺在胎儿时期对成人实践的影响比在胎儿成年之前的任何时候都要直接；这确实是成人和儿科肺科医生之间的一个接口领域。肺在胎儿内发育，胎儿(通常)在成人的子宫内发育，成人可能是吸烟者或药物滥用者，或者也可能正在接受哮喘或囊性纤维化(CF)等呼吸系统疾病的治疗。母亲的一些合法药物治疗可能会对胎儿肺发育产生不利影响。围绕出生和童年早期的事件也可能留下永久的遗产，其成果可能只有在中年才会出现。对正常发育的认识是理解本专著中其他地方描述的疾病的影响的基础。对发育过程中事件的研究可能会让人们对以后生命中的病理生理过程有新的见解，如胎儿离子转运和CF。因此，本章强调病理生理学和疾病状态相联系的主题。本章的目的是描述肺是如何发展的，特别强调与成年医生相关的情况，而不是试图给出一个
At first sight, adult physicians may feel that intra-uterine lung development is of little interest and importance to them. Paradoxically however, the developing lung impacts more directly on adult practice during foetal life than at any time until the foetus becomes an adult; this is truly an area of interface between adult and paediatric pulmonologists. The lung develops within a foetus which is (usually) within the uterus of an adult, who may be a smoker, or a substance abuser, or may also be receiving treatment for a respiratory condition such as asthma or cystic fibrosis (CF). Some legitimate drug treatment of the mother may adversely impact on foetal lung development. Events around birth and early childhood may also leave a permanent legacy, the fruits of which may appear only in middle age. An appreciation of normal development is fundamental to understanding the effects of the diseases which are described elsewhere in this monograph. The study of events during development may allow new insights into pathophysiological processes in later life, such as foetal ion transport and CF. This chapter therefore emphasizes themes where pathophysiology and disease states are linked. The aim of this chapter is to describe how the lung develops, with a particular emphasis on conditions relevant to adult physicians, rather than trying to give a
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DOI：
10.1152/ajplung.1995.268.4.l589
发表时间：
1995-04-01
影响因子：
4.9
作者：
KAWAI, N;BLOCH, DB;BLOCH, KD
通讯作者：
BLOCH, KD
婴儿气道反应性：对乙酰甲胆碱和异丙肾上腺素呈阳性反应。
DOI：
10.1152/jappl.1987.62.3.1155
发表时间：
1987
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Tepper,RS
通讯作者：
Tepper,RS
影响因子：
15.9
作者：
Huffman, JA;Hull, WM;Whitsett, JA
通讯作者：
Whitsett, JA
影响因子：
15.9
作者：
BRANNON, TS;NORTH, AJ;SHAUL, PW
通讯作者：
SHAUL, PW
DOI：
10.1164/ajrccm.161.3.9903153
发表时间：
2000-03-01
影响因子：
24.7
作者：
Nogee, LM;Wert, SE;Whitsett, JA
通讯作者：
Whitsett, JA