High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma
High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma
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DOI：
10.1038/sj.onc.1203535
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发表时间：
2000-05-11
期刊：
影响因子：
8
通讯作者：
Hung, MC
中科院分区：
文献类型：
--
作者：
Xia, WY;Lau, YK;Hung, MC
Maspin是蛋白酶抑制剂丝氨酸蛋白酶抑制剂家族的成员，已知其具有肿瘤抑制功能，然而，其表达水平与人类癌症中的存活之间的关联尚未被证实。应用免疫组织化学方法检测44例口腔鳞癌组织中maspin蛋白的表达，发现66%的口腔鳞癌组织中maspin蛋白呈低、中水平表达，34%的口腔鳞癌组织中maspin蛋白呈高水平表达。发现除了一个细胞外，所有细胞都表达低水平或不表达maspin蛋白。我们还比较了口腔鳞癌的临床病理特征和maspin表达水平，发现maspin高表达与无淋巴结转移有关，更重要的是，我们发现maspin高表达与总生存率显著相关，提示maspin高表达可能是口腔鳞癌良好的预后标志。
Maspin, a member of the serpin family of protease inhibitors, is known to have tumor-suppressor functions, However, the association between its expression level and survival has not been demonstrated in human cancer. Using the immunohistochemical technique to examine the expression levels of maspin in 44 cases of oral squamous cell carcinoma (SCC), we found that 66% of the cases expressed low to intermediate levels of maspin and 34% of the cases expressed high levels of maspin, We further examined maspin protein expression in a series of sis SCC cell lines from the head and neck, and found that all but one expressed low or no maspin protein. We also compared the clinicopathological features of the oral SCC cases with the maspin expression level, and found that high maspin expression was associated with the absence of lymph node metastasis, More importantly,,ve showed that higher maspin expression was significantly associated with better rates of overall survival, suggesting that high maspin expression may be a favorable prognostic marker for oral SCC.