Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults
Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults
复制标题
DOI：
10.1016/j.ijheh.2015.03.008
复制
发表时间：
2015-07-01
影响因子：
6
通讯作者：
Su, Ta-Chen
中科院分区：
文献类型：
--
作者：
Tsai, Meng-Shan;Lin, Chien-Yu;Su, Ta-Chen
背景：很少有研究探讨全氟烷基物质（PFAS）与青少年和年轻人生殖激素之间的关联。目的：本研究旨在调查青少年和年轻人中 PFAS 与生殖激素的关系。方法：我们从 1992 年至 2000 年的大规模尿液筛查人群中招募了 540 名 12-30 岁的受试者，并通过邮件或/和电话邀请建立了 2006 年至 2008 年的队列。使用 Waters ACQUITY UPLC 系统和 Waters Quattro Premier XE 三重四极杆质谱仪分析血清 PFAS 水平。使用 Architect 随机存取测定系统通过免疫发光测定法测量血清生殖激素水平。根据多元回归模型中的检测限将 PFAS 水平分为不同的百分位数，以分析生殖激素水平与 PFAS 暴露之间的关联。结果：与 12-17 岁女性组的参考类别相比，与全氟辛酸 (PFOA) 的第 90 个百分位数类别相关的性激素结合球蛋白 (SHBG) 调整后平均血清水平显着下降。 12-17岁男性组中促卵泡激素（FSH）水平的显着降低与全氟辛烷磺酸（PFOS）的不同百分位数类别和12-17岁女性组中全氟十一烷酸（PFUA）的不同百分位数类别相关。 12-17 岁女性的血清 FSH 水平也随着 PFUA 的不同百分位数类别而降低。另一方面，在 12-17 岁女性群体中，PFOS 的不同百分位类别与血清睾酮水平之间存在显着负相关。结论：我们发现台湾年轻人群中 PFOA、PFOS 和 PFUA 的血清浓度与 SHBG、FSH 和睾酮水平呈负相关，并且这种影响在 12-17 岁女性中最强。需要进一步的研究来确定这些关联是否存在因果关系。 (C) 2015 爱思唯尔有限公司。版权所有。
Background: Few studies have explored the association between perfluoroalkyl substances (PFAS) and reproductive hormones in adolescents and young adults. Objectives: This study aimed to investigate the association of PFAS with reproductive hormones in adolescents and young adults.Methods: We recruited 540 subjects aged 12-30 years from a 1992 to 2000 mass urine screening population and established a cohort from 2006 to 2008 via invitations by mail or/and telephone. Serum PFAS levels were analyzed with a Waters ACQUITY UPLC system coupled with a Waters Quattro Premier XE triple quadrupole mass spectrometer. Serum reproductive hormone levels were measured by immunoluminometric assay with an Architect random access assay system. PFAS levels were divided into different percentiles according to their detection limits in the multiple regression models to analyze associations between reproductive hormone levels and exposure with PFAS.Results: The adjusted mean serum level of sex hormone-binding globulin (SHBG) decreased significantly in association with the 90th percentile categories of perfluorooctanoic acid (PFOA) compared with a reference category for the females in the 12-17-year-old group. The follicle-stimulating hormone (FSH) levels were significantly decreased in association with the different percentile categories of perfluorooctane sulfonate (PFOS) in the male 12-17-year-old group and the different percentile categories of perfluoroundecanoic acid (PFUA) in the female 12-17-year-old group. The serum FSH levels in the females aged 12-17 were also decreased in association with the different percentile categories of PFUA. On the other hand, there was a significantly negative association between the different percentile categories of PFOS and the serum testosterone level among the female 12-17-year-old group.Conclusions: We found that the serum concentrations of PFOA, PFOS, and PFUA were negatively associated with the serum levels of SHBG, FSH, and testosterone in the young Taiwanese population and that these effects were the strongest in the females aged 12-17. Further studies are needed to determine whether these associations are causal. (C) 2015 Elsevier GmbH. All rights reserved.