Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model.
Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model.
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DOI：
10.1016/j.antiviral.2016.05.011
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发表时间：
2016-08
影响因子：
7.6
通讯作者：
Wobus CE
中科院分区：
文献类型：
--
作者：
Kolawole AO;Rocha-Pereira J;Elftman MD;Neyts J;Wobus CE
最近开发的人类诺如病毒（HuNoV） B细胞培养和小鼠模型有望用于药物发现和开发，但其抗病毒研究的适用性尚未得到评估。我们证明了核苷类似物2′- c -甲基胞苷（2CMC）对人B细胞BJAB细胞株和Balb/c Rag/ γ链缺陷（Rag-γc−/−）小鼠HuNoV复制的抑制作用。这些数据表明，这两个模型对未来研究和开发用于治疗HuNoV感染的抗病毒药物具有适用性。
The recently developed human norovirus (HuNoV) B cell culture and mouse models hold promise for drug discovery and development but their suitability for antiviral studies has not been assessed. We demonstrate the inhibitory effect of the nucleoside analogue 2′-C-methylcytidine (2CMC) on HuNoV replication in the human B cell BJAB cell line and in Balb/c Rag/gamma chain-deficient (Rag-γc−/−) mice. These data suggest the applicability of both models for future study and development of antiviral drugs for the treatment of HuNoV infections.