Occurrence and transfer of benzophenone-type ultraviolet filters from the pregnant women to fetuses
Occurrence and transfer of benzophenone-type ultraviolet filters from the pregnant women to fetuses
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二苯甲酮类紫外线过滤剂孕妇向胎儿的发生和传播
DOI：
10.1016/j.scitotenv.2020.138503
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发表时间：
2020-07-15
影响因子：
9.8
通讯作者：
Zhang, Tao
中科院分区：
文献类型：
--
作者：
Song, Shiming;He, Yuan;Zhang, Tao
二苯甲酮（BP）型紫外线（UV）过滤剂广泛用于个人护理产品。其中一些已被确定为内分泌干扰化学品。然而，很少有人知道的发生BP型紫外线过滤器配对母胎样本。在这项研究中，我们调查了八个BP型紫外线过滤器的发生在配对母胎样本收集来自中国南方。在目标分析物中，只有二苯甲酮-3（BP-3）在母胎样本中经常被检测到（检测率> 80%），即，母体血清（MS）、脐带血清（CS）、母体尿液（MU）和羊水（AF）。BP-3是MS（中位数：0.14 ng/mL）、CS（0.16）和AF（0.12）中的主要化合物;而MU以二苯甲酮-1（BP-1，2.85）为主。中值CS/MS比（即，4-羟基二苯甲酮（4-OH-BP，2.35）、BP-1（1.52）、二苯甲酮-4（BP-4，1.06）和BP-3（1.03）的胎盘转移率高于1.0，表明胎儿中这些化学品的暴露水平高于母亲。MS与CS之间BP-3浓度呈显著正相关（r = 0.667，p < 0.001），提示MS可作为胎儿BP-3暴露的一个指标。此外，4-OH-BP、BP-1、BP-3和二苯甲酮-8（BP-8）的CS/MS比随着分子量或log K-ow的降低而增加。被动扩散可能在这些BP型UV过滤剂的胎盘转移中起重要作用。MU/MSBP-3比值（5.86）相对高于MU/MSBP-1比值（0.89），表明BP-3在尿液中排泄迅速。本研究首次在中国的MS、CS、MU和AF样品中发现了8种BP型紫外滤光剂。
Benzophenone (BP)-type ultraviolet (UV) filters are widely used in personal care products. Some of them have been identified as endocrine disrupting chemicals. However, little is known about the occurrence of BP-type UV filters in paired maternal-fetal samples. In this study, we investigated the occurrence of eight BP-type UV filters in paired maternal-fetal samples collected from Southern China. Among target analytes, only benzophenone-3 (BP-3) was frequently (detection rate > 80%) detected in maternal-fetal samples, i.e., maternal serum (MS), cord serum (CS), maternal urine (MU) and amniotic fluid (AF). BP-3 was the dominant compound in MS (median: 0.14 ng/mL), CS (0.16) and AF (0.12); whereas MU was dominated by benzophenone-1 (BP-1, 2.85). The median CS/MS ratios (i.e., placental transfer rates) of 4-hydroxy benzophenone (4-OH-BP, 2.35), BP-1 (1.52), benzophenone-4 (BP-4, 1.06), and BP-3 (1.03) were higher than 1.0, suggesting that exposure levels of these chemicals in fetuses were greater than those in mothers. Significant positive correlations (r = 0.667, p < 0.001) of BP-3 concentrations were found between MS and CS, which suggested that MS could be an indicator of fetal exposure to BP-3. Furthermore, the CS/MS ratios of 4-OH-BP, BP-1, BP-3, and benzophenone-8 (BP-8) increased with decreasing molecular weight or log K-ow. Passive diffusion may play an important role in placental transfer of these BP type UV filters. The MU/MSBP-3 ratio (5.86) was relatively higher than that of MU/MSBP-1 (0.89), which indicated that BP-3 excretes rapidly in urine. The present study documents the occurrence of eight BP-type UV filters in matched MS, CS, MU and AF samples for the first time in China.