Absorption of drugs from the rat small intestine.
Absorption of drugs from the rat small intestine.
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药物从大鼠小肠的吸收。
DOI：
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发表时间：
1958
影响因子：
3.5
通讯作者：
C. Hogben
中科院分区：
文献类型：
--
作者：
L. Schanker;D. Tocco;B. Brodie;C. Hogben
大量药物的相对吸收速率是通过将药物溶液灌注麻醉大鼠的整个小肠来测量的。小肠的单次灌注区分了非常快速的吸收和不太快速的吸收。药物溶液通过肠的连续再循环将不太快速的吸收与非常缓慢的吸收分开。溶液中有机电解质的电离度似乎是决定其从大鼠小肠吸收的最重要因素之一。酸性药物的pK α 9大于3时吸收迅速。碱性药物的pK α 9小于8时吸收迅速。较强的酸和碱吸收相对较慢，非常强的酸和碱的吸收是不可察觉的。大鼠小肠吸收药物的最佳解释是假设未离子化药物通过屏障（本质上可能是类脂）的简单扩散。
The relative rates of absorption of a large number of drugs have been measured by perfusing solutions of drugs through the entire small intestine of the anesthetized rat. A single perfusion of the small intestine differentiated very rapid absorption from less rapid absorption. A continuous recirculation of the drug solution through the intestine separated less rapid absorption from very slow absorption. The degree of ionization of an organic electrolyte in solution appears to be one of the most important factors determining its absorption from the rat small intestine. Acidic drugs were rapidly absorbed if their pK a 9s were greater than 3. Basic drugs were rapidly absorbed if their pK a 9s were less than 8. The stronger acids and bases were relatively slowly absorbed and the absorption of very strong acids and bases was imperceptible. Absorption of drugs from the rat small intestine can be best explained by assuming simple diffusion of unionized drug across a barrier which may be lipoidal in nature.