Exploring Social and Demographic Factors as Determinants of Intestinal Inflammation in Very Low Birth-Weight Infants.
Exploring Social and Demographic Factors as Determinants of Intestinal Inflammation in Very Low Birth-Weight Infants.
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DOI：
10.1097/anc.0000000000000951
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发表时间：
2021-12-01
期刊：
影响因子：
--
通讯作者：
Parker LA
中科院分区：
文献类型：
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作者：
Desorcy-Scherer K;Weaver M;Parker LA
极低出生体重（VLBW）婴儿尤其容易受到包括坏死性小肠结肠炎在内的炎症性疾病的影响。尽管社会和人口因素对婴儿健康结果有影响，但它们与肠道炎症的关系尚不清楚。探讨母亲种族、母亲社会经济地位和婴儿性别对极低出生体重儿肠道炎症的影响。这是对 143 名妊娠 ≤ 32 周且体重≤ 1250 克婴儿的随机对照试验的现有数据进行的二次分析。在之前的研究中，在第 3 周和第 6 周收集了粪便钙卫蛋白和 S100A12。婴儿样本是根据这些结果的可用性确定的，作为本研究的肠道炎症生物标志物。一般线性混合模型评估生物标志物与社会和人口因素之间的关系。胎龄、抗生素暴露、母亲自己的母乳喂养、敏锐度和样本采集周数被用作控制变量。样本包括 124 名婴儿。 52 人 (42%) 是非裔美国人，86 人 (69%) 享受医疗补助，65 人 (53%) 是男性。非裔美国婴儿 (P=.02) 和有私人保险的婴儿 (P=.009) 的粪便钙卫蛋白水平较高，性别之间没有发现差异。 S100A12 水平与婴儿性别、母亲种族或社会经济地位之间没有关联。在照顾极低出生体重婴儿时，考虑社会和人口因素可能很重要。需要进一步探索社会或人口因素与肠道炎症之间关联的因素。
Very low-birth-weight (VLBW) infants are disproportionately affected by inflammatory morbidities including necrotizing enterocolitis. Despite the influence of social and demographic factors on infant health outcomes, their relationship with intestinal inflammation is unknown. To explore the influence of maternal race, maternal socioeconomic status and infant sex on intestinal inflammation in VLBW infants. This was a secondary analysis of existing data from a randomized controlled trial of 143 infants ≤ 32 weeks gestation and ≤ 1250g. In the previous study, fecal calprotectin and S100A12 were collected at weeks 3 and 6. The infant sample was determined based on the availability of these results which served as intestinal inflammation biomarkers for the present study. General linear mixed models assessed the relationship between biomarkers and social and demographic factors. Gestational age, antibiotic exposure, mother’s own milk feeding, acuity, and week of sample collection were used as control variables. The sample included 124 infants. Fifty-two (42%) were African American, 86 (69%) had Medicaid coverage and 65 (53%) were male. Fecal calprotectin levels were higher in African American infants (P=.02) and infants with private insurance coverage (P=.009), no difference was found between sexes. There was no association between S100A12 levels and infant sex, maternal race, or socioeconomic status. Consideration of social and demographic factors may be important when caring for VLBW infants. Further exploration of factors contributing to associations between social or demographic factors and intestinal inflammation is needed.