Multivalent glycoconjugates as anti-pathogenic agents.
Multivalent glycoconjugates as anti-pathogenic agents.
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DOI：
10.1039/c2cs35408j
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发表时间：
2013-06-07
影响因子：
46.2
通讯作者：
Imberty A
中科院分区：
文献类型：
--
作者：
Bernardi A;Jiménez-Barbero J;Casnati A;De Castro C;Darbre T;Fieschi F;Finne J;Funken H;Jaeger KE;Lahmann M;Lindhorst TK;Marradi M;Messner P;Molinaro A;Murphy PV;Nativi C;Oscarson S;Penadés S;Peri F;Pieters RJ;Renaudet O;Reymond JL;Richichi B;Rojo J;Sansone F;Schäffer C;Turnbull WB;Velasco-Torrijos T;Vidal S;Vincent S;Wennekes T;Zuilhof H;Imberty A
多价性在生物过程中起着重要作用，特别是在病原微生物与其宿主之间的关系中，涉及蛋白质-聚糖识别。这些相互作用发生在感染的第一步，用于宿主和细菌之间的特异性识别，但也发生在免疫反应的不同阶段。研究这种相互作用的高亲和力的配体的搜索涉及的碳水化合物的头部基团与不同的支架和连接器的组合，产生多价的糖化合物与控制的空间和拓扑参数。通过干扰病原体粘附，包括糖共聚物、糖簇、糖树枝状聚合物和糖纳米颗粒的此类糖化合物具有改善或取代现在被耐药性破坏的抗生素治疗的潜力。多价糖缀合物也已用于刺激先天性和适应性免疫系统，例如使用基于碳水化合物的疫苗。细菌在其表面上存在天然多价糖缀合物，例如脂多糖和S-层，其也可以在抗感染策略中被利用或靶向。
Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein–glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.
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影响因子：
4.3
作者：
Cecioni, Samy;Lalor, Ruth;Vidal, Sebastien
通讯作者：
Vidal, Sebastien
影响因子：
3.2
作者：
Branderhorst, Hilbert M.;Kooij, Raymond;Pieters, Roland J.
通讯作者：
Pieters, Roland J.
影响因子：
2.7
作者：
Andre, Sabine;Jarikote, Dilip V.;Gabius, Hans-Joachim
通讯作者：
Gabius, Hans-Joachim
影响因子：
4.3
作者：
Cecioni, Samy;Oerthel, Vincent;Vidal, Sebastien
通讯作者：
Vidal, Sebastien
影响因子：
15
作者：
Arosio, D;Fontanella, M;Ungaro, R
通讯作者：
Ungaro, R