Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells.
Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells.
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DOI：
10.1186/2045-3701-3-39
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发表时间：
2013-10-09
影响因子：
7.5
通讯作者：
Lee MG
中科院分区：
文献类型：
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作者：
Gu B;Lee MG
表观遗传机制是理解基因表达调控网络的基础，这些基因表达调控网络支配干细胞的维持和分化。甲基化组蛋白H3赖氨酸4（H3K4）已成为基因转录的关键表观遗传信号，它是由几个特定的H3K4甲基转移酶和脱甲基酶动态调节。最近的研究已经描述了H3K4甲基化修饰剂控制干细胞自我更新和谱系承诺的新的表观遗传机制。干细胞生物学的这些进展将对癌症干细胞和再生医学的研究领域产生重大影响。本文就H3K4甲基化修饰物在调控胚胎干细胞和成体干细胞命运中的作用作一综述。
Epigenetic mechanisms are fundamental to understanding the regulatory networks of gene expression that govern stem cell maintenance and differentiation. Methylated histone H3 lysine 4 (H3K4) has emerged as a key epigenetic signal for gene transcription; it is dynamically modulated by several specific H3K4 methyltransferases and demethylases. Recent studies have described new epigenetic mechanisms by which H3K4 methylation modifiers control self-renewal and lineage commitments of stem cells. Such advances in stem cell biology would have a high impact on the research fields of cancer stem cell and regenerative medicine. In this review, we discuss the recent progress in understanding the roles of H3K4 methylation modifiers in regulating embryonic and adult stem cells’ fates.
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影响因子：
4.5
作者：
Albert M;Schmitz SU;Kooistra SM;Malatesta M;Morales Torres C;Rekling JC;Johansen JV;Abarrategui I;Helin K
通讯作者：
Helin K
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3.7
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Diehl F;Brown MA;van Amerongen MJ;Novoyatleva T;Wietelmann A;Harriss J;Ferrazzi F;Böttger T;Harvey RP;Tucker PW;Engel FB
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Engel FB
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Song, Ji-Joon
影响因子：
10.5
作者：
Clouaire, Thomas;Webb, Shaun;Bird, Adrian
通讯作者：
Bird, Adrian
影响因子：
64.8
作者：
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