Role of microglia in glioma biology
Role of microglia in glioma biology
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DOI：
10.1002/jemt.1125
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发表时间：
2001-07-15
影响因子：
2.5
通讯作者：
Schartner, J
中科院分区：
文献类型：
--
作者：
Badie, B;Schartner, J
小胶质细胞是一种分化的组织巨噬细胞，被认为是中枢神经系统中最具可塑性的细胞群。作为对病理条件的反应，静息的小胶质细胞经历一个刻板的激活过程，并变得能够吞噬、抗原递送和淋巴细胞激活。考虑到它们的免疫效应功能，并不令人惊讶；几乎在每个中枢神经系统疾病过程中都会看到小胶质细胞聚集，包括恶性脑瘤或恶性胶质瘤。虽然这些细胞在中枢神经系统炎症过程中的功能正在研究中，但它们在恶性胶质瘤生物学中的作用仍不清楚。一方面，小胶质细胞可能代表了中枢神经系统的抗肿瘤反应，这种反应被胶质瘤细胞局部分泌的免疫抑制因子所灭活。另一方面，考虑到小胶质细胞能够分泌多种免疫调节细胞因子，有可能它们被胶质瘤吸引而促进肿瘤生长。更好地了解小胶质细胞-胶质瘤的相互作用将有助于设计针对这些致命肿瘤的基于免疫的新疗法。(C)2001年Wiley-Liss，Inc.
Microglia, a type of differentiated tissue macrophage, are considered to be the most plastic cell population of the central nervous system (CNS). In response to pathological conditions, resting microglia undergo a stereotypic activation process and become capable of phagocytosis, antigen presentation, and lymphocyte activation. Considering their immune effector function, it is not; surprising to see microglia accumulation in almost every CNS disease process, including malignant brain tumors or malignant gliomas. Although the function of these cells in CNS inflammatory processes is being studied, their role in malignant glioma biology remains unclear. On one hand, microglia may represent a CNS anti-tumor response, which is inactivated by local secretion of immunosuppressive factors by glioma cells. On the other hand, taking into account that microglia are capable of secreting a variety of immunomodulatory cytokines, it is possible that they are attracted by gliomas to promote tumor growth. A better understanding of microglia-glioma interaction will be helpful in designing novel immune-based therapies against these fatal tumors. (C) 2001 Wiley-Liss, Inc,