Intestinal mucins in colonization and host defense against pathogens
Intestinal mucins in colonization and host defense against pathogens
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DOI：
10.4269/ajtmh.1999.60.10
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发表时间：
1999-04-01
影响因子：
3.3
通讯作者：
Chadee, K
中科院分区：
文献类型：
--
作者：
Belley, A;Keller, K;Chadee, K
肠粘蛋白是宿主抵抗肠道病原体的第一道防线的关键组分。这些由特化外分泌杯状细胞分泌的大的糖缀合物形成粘性凝胶，其捕获微生物和刺激物并限制它们扩散到肠上皮。此外，它们允许土著细菌植物群定植，防止病原微生物附着。微生物与粘蛋白的相互作用涉及粘蛋白的碳水化合物侧链和微生物粘附素分子。某些微生物和疾病状态可能改变粘蛋白的生物化学或表达。虽然这些改变很可能导致疾病过程，但这些现象的全部影响仍不清楚。粘蛋白分泌细胞系的发展促进了粘蛋白生物学的研究，并帮助我们了解粘蛋白-微生物的相互作用。
Intestinal mucins are key components of the first line of host defense against intestinal pathogens. These large glycoconjugates secreted by specialized exocrine goblet cells form viscous gels that trap microorganisms and irritants and limit their diffusion to the intestinal epithelium. Moreover, they allow for colonization by indigenous bacterial flora that prevents attachment of pathogenic microbes. The interaction between microbes and mucins involves mucin carbohydrate side chains and microbial adhesin molecules. Certain microorganisms and disease states may alter mucin biochemistry or expression. Although these alterations most likely contribute to disease processes, the full impact of these phenomena are still unclear. The development of mucin-secreting cell lines has facilitated the study of mucin biology and aided our understanding of mucin-microbial interactions.