A pilot study of long-term effects of a novel obesity treatment:: omentectomy in connection with adjustable gastric banding
A pilot study of long-term effects of a novel obesity treatment:: omentectomy in connection with adjustable gastric banding
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DOI：
10.1038/sj.ijo.0801871
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发表时间：
2002-02-01
影响因子：
4.9
通讯作者：
Arner, P
中科院分区：
文献类型：
--
作者：
Thörne, A;Lönnqvist, F;Arner, P
目的：为了确定与减肥手术相关的内脏脂肪减少是否可以改善肥胖受试者的体重减轻和代谢状况。在一项单中心、随机、对照的初步试验中，我们将50名严重肥胖的受试者（体重指数>35 kg/m2）与单独使用可调节胃束带（AGB）（11名男性和14名女性），或AGB加手术切除整个大网膜（11名男性和14名女性）。患者定期随访2年，并在0和24个月检查身体成分和代谢profile.RESULTS：对照组和网膜切除患者之间没有显着差异，观察在基线。切除的大网膜占0.8 ± 0.4%（平均值± s.d.）身体脂肪总量。在2年随访时，两组的体重均出现预期下降，代谢特征均得到改善。虽然网膜切除受试者倾向于比对照受试者减轻更多的体重，但差异无统计学意义，两组之间腰臀比和矢状径的变化也无差异。然而，口服葡萄糖耐量、胰岛素敏感性、空腹血糖和胰岛素的改善在网膜切除组比对照组高2-3倍（P从0.009到0.04），这在统计学上与体重指数的下降无关。两组间血脂无差异。没有相关的不良影响网膜切除术observed.CONCLUSIONS：网膜切除术，当与AGB一起进行，有显着的积极和长期的影响，对肥胖受试者的葡萄糖和胰岛素代谢谱。
AIM: To determine whether visceral fat reduction in connection with bariatric surgery could improve weight loss and metabolic profile of obese subjects.PATIENTS AND METHODS: In a one-center, randomized and controlled pilot trial we assigned 50 subjects with severe obesity (body mass index >35 kg/m(2)) to either adjustable gastric banding (AGB) alone (11 men and 14 women), or AGB plus surgical removal of the total greater omentum (11 men and 14 women). The patients were followed at regular intervals for 2y and examined at 0 and 24 months with respect to body composition and metabolic profile.RESULTS: No significant differences between control and omentectomized patients were observed at baseline. The removed greater omentum constituted 0.8 +/- 0.4% (mean +/- s.d.) of total body fat. At 2y follow-up there was an expected decrease in body weight and an improvement in metabolic profile in both groups. Although omentectomized subjects tended to lose more weight than control subjects the difference was not statistically significant and changes in waist-to-hip ratio and saggital diameter did not differ between groups. However, the improvements in oral glucose tolerance, insulin sensitivity and fasting plasma glucose and insulin were 2-3 times greater in omentectomized as compared to control subjects (P from 0.009 to 0.04), which was statistically independent of the loss in body mass index. No differences in blood lipids between the groups were recorded. No adverse effects related to omentectomy were observed.CONCLUSIONS: Omentectomy, when performed together with AGB, has significant positive and long-term effects on the glucose and insulin metabolic profiles in obese subjects.