Why should parasite resistance be costly?
Why should parasite resistance be costly?
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DOI：
10.1016/s1471-4922(01)02203-6
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发表时间：
2002-03-01
影响因子：
9.6
通讯作者：
Stevens, L
中科院分区：
文献类型：
--
作者：
Rigby, MC;Hechinger, RF;Stevens, L
寄生虫的抵抗力有时与适应性成本有关。耐药性的代价在流行病学、宿主-寄生虫相互作用的生态学和进化中具有根本的重要性。抗性的成本通常被设想为将有限的资源从其他性状重新分配给抗性机制的成本。这种流行的范式导致了大量的研究，假设抵抗的健康成本。我们对这一趋势进行了评论，并提出了各种抵抗手段和机制的工作框架。在这些手段和机制，我们认为，许多不太可能产生重大的健身成本。
Parasite resistance is sometimes associated with fitness costs. Costs of resistance are fundamentally important in epidemiology, and in the ecology and evolution of host-parasite interactions. The cost of resistance is often envisioned as the cost of re-allocating limiting resources to resistance machinery from other traits. This popular paradigm has resulted in a spate of research that assumes a fitness cost to resistance. We comment on this trend and propose a working framework of various resistance means and mechanisms. Within these means and mechanisms, we suggest that many are not likely to incur significant fitness costs.