Enhanced spontaneous functional connectivity of the superior temporal gyrus in early deafness.
Enhanced spontaneous functional connectivity of the superior temporal gyrus in early deafness.
复制标题
早期耳聋颞上回自发功能连接增强
DOI：
10.1038/srep23239
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发表时间：
2016-03-17
影响因子：
4.6
通讯作者：
Yu C
中科院分区：
文献类型：
--
作者：
Ding H;Ming D;Wan B;Li Q;Qin W;Yu C
早期听觉剥夺可能驱使听觉皮层对非听觉感觉信息进行跨通道加工。在最近的一项研究中，我们发现早期耳聋被试在视觉空间工作记忆中双侧上级颞回（STG）的激活增加，但STG相关的自发功能网络的组织变化及其认知相关性仍然是未知的。为了阐明这一问题，我们应用静息态功能磁共振成像对42例早期耳聋（艾德）和40例听力正常（HC）。我们还获得了这些被试的视觉空间和数字n-back工作记忆（WM）信息。与听力正常者相比，艾德被试在空间域和数字域的视觉工作记忆任务中表现出更快的反应时。此外，艾德受试者的STG（特别是右半球）和双侧前扣带皮层和背侧前扣带皮层之间的功能连接显着增加。最后，STG的功能连接可以预测视觉空间WM性能，即使在控制数值WM性能。我们的研究结果表明，早期听觉剥夺可以加强STG的自发功能连接，这可能有助于该区域的跨通道参与视觉工作记忆。
Early auditory deprivation may drive the auditory cortex into cross-modal processing of non-auditory sensory information. In a recent study, we had shown that early deaf subjects exhibited increased activation in the superior temporal gyrus (STG) bilaterally during visual spatial working memory; however, the changes in the organization of the STG related spontaneous functional network and their cognitive relevance are still unknown. To clarify this issue, we applied resting state functional magnetic resonance imaging on 42 early deafness (ED) and 40 hearing controls (HC). We also acquired the visual spatial and numerical n-back working memory (WM) information in these subjects. Compared with hearing subjects, the ED exhibited faster reaction time of visual WM tasks in both spatial and numerical domains. Furthermore, ED subjects exhibited significantly increased functional connectivity between the STG (especially of the right hemisphere) and bilateral anterior insula and dorsal anterior cingulated cortex. Finally, the functional connectivity of STG could predict visual spatial WM performance, even after controlling for numerical WM performance. Our findings suggest that early auditory deprivation can strengthen the spontaneous functional connectivity of STG, which may contribute to the cross-modal involvement of this region in visual working memory.