Physical activity and colorectal cancer: The Fukuoka colorectal cancer study
Physical activity and colorectal cancer: The Fukuoka colorectal cancer study
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DOI：
10.1111/j.1349-7006.2006.00282.x
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发表时间：
2006-10-01
期刊：
影响因子：
5.7
通讯作者：
Imaizumi, Nobutoshi
中科院分区：
文献类型：
--
作者：
Isomura, Kayoko;Kono, Suminori;Imaizumi, Nobutoshi
在过去的几十年里，日本的结直肠癌病例数量有所增加，目前发病率位居世界前列。目前在福冈结直肠癌研究中进行的这项调查，包括778名20-74岁的患者和767名对照，按分部位考察了体力活动和结直肠癌风险之间的关系。通过问卷调查和访谈来评估与工作相关的体力活动和闲暇时间。近端和远端结肠以及直肠部位的划分显示出明显的部位依赖保护效应，并对吸烟、饮酒、体重指数和年龄进行了调整。在男性中，较多的与工作相关的体力活动与远端结肠和直肠的风险显著降低相关(P=0.047.0 1和0.0 2)，而全面、适度或剧烈的非工作体力活动对直肠的影响有限(分别为P=0.0 1和0.004)。在女性中，与工作相关的体力活动和中等或剧烈的非工作体力活动也具有保护作用，但仅限于远端结肠。研究前10年对BMI影响的单独评估显示，男性肥胖风险增加，但女性肥胖风险增加，仅限于远端结肠和直肠。本研究的结果表明，在日本人中，与工作和休闲时间相关的体力活动会产生有益的影响，但对近端结肠没有影响。
The number of cases of colorectal cancer in Japan has increased over the past few decades, and incidence rates are now among the highest in the world. The present investigation within the Fukuoka Colorectal Cancer Study, including 778 cases and 767 controls aged 20-74 years, examined the association between physical activity and colorectal cancer risk by subsite. Employment-associated and leisure time physical activity was assessed by a questionnaire and interview. Division of sites into the proximal and distal colon, as well as the rectum, revealed clear site-dependent protective effects, with adjustment for smoking, alcohol consumption, BMI and age. In males, greater job-related physical activity was associated with significant reduction of risk in the distal colon and rectum (P = 0.047 and 0.02, respectively), whereas total and moderate or hard non-job physical activity exerted effects limited to the rectum (P = 0.01 and 0.004, respectively). In females, job-related physical activity and moderate or hard non-job physical activity was also protective, but only in the distal colon. Separate assessment of the influence of BMI 10 years previous to the study showed increase in risk with obesity in males but not in females, limited to distal colon and rectum. The results of the present study indicate that physical activity associated with work and leisure-time exerts beneficial effects in Japanese, but not on the proximal colon.