Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis.
Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis.
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用来自墨角藻的褐藻糖胶预处理可通过抑制内源性和外源性细胞凋亡来预防刀豆蛋白 A 诱导的急性肝损伤
DOI：
10.1371/journal.pone.0152570
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Guo C
中科院分区：
文献类型：
--
作者：
Li J;Chen K;Li S;Liu T;Wang F;Xia Y;Lu J;Zhou Y;Guo C
探讨墨角藻多糖硫酸酯对刀豆球蛋白A（ConA）诱导的小鼠急性肝损伤的影响。褐藻糖胶预处理通过抑制炎性细胞因子，如肿瘤坏死因子α（TNF-α）和干扰素γ（IFN-γ），保护肝功能（ALT、AST和组织病理学变化）。此外，褐藻糖胶可抑制Bax、Bid、Bcl-2、Bcl-xL和Caspase 3、8和9介导的内源性和外源性凋亡，其作用与TRADD/TRAF 2和JAK 2/STAT 1信号通路有关。结果表明，墨角藻依聚糖硫酸酯通过抑制TNF-α和IFN-γ激活的TRADD/TRAF 2和JAK 2/STAT 1通路介导的内源性和外源性细胞凋亡，减轻ConA诱导的急性肝损伤。这些发现可能为T细胞相关性肝炎提供潜在的强大疗法。
This study aimed to explore the effects of fucoidan from Fucus vesiculosus on concanavalin A (ConA)-induced acute liver injury in mice. Pretreatment with fucoidan protected liver function indicated by ALT, AST and histopathological changes by suppressing inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ). In addition, intrinsic and extrinsic apoptosis mediated by Bax, Bid, Bcl-2, Bcl-xL and Caspase 3, 8, and 9 were inhibited by fucoidan and the action was associated with the TRADD/TRAF2 and JAK2/STAT1 signal pathways. Our results demonstrated that fucoidan from Fucus vesiculosus alleviated ConA-induced acute liver injury via the inhibition of intrinsic and extrinsic apoptosis mediated by the TRADD/TRAF2 and JAK2/STAT1 pathways which were activated by TNF-α and IFN-γ. These findings could provide a potential powerful therapy for T cell-related hepatitis.